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Comment
. 2021 Aug 25;6(4):e0024721.
doi: 10.1128/mSphere.00247-21. Epub 2021 Jul 7.

mSphere of Influence: Host Metabolism Is an Integral Part of the Immune Response to Infectious Diseases

Jeffrey M Collins  1
Affiliations
Comment

mSphere of Influence: Host Metabolism Is an Integral Part of the Immune Response to Infectious Diseases

Jeffrey M Collins. mSphere. .

Abstract

Jeff Collins is a physician scientist in the Division of Infectious Diseases at Emory University focused on using metabolomics and systems biology to better understand the pathophysiology of tuberculosis disease, identify new biomarkers, and elucidate targets for host-directed therapeutics. In this mSphere of Influence article, he reflects on how the paper "Succinate is an inflammatory signal that induces IL-1β through HIF-1α" by Tannahill et al. (G. M. Tannahill, A. M. Curtis, J. Adamik, E. M. Palsson-McDermott, et al., Nature 496:238-242, 2013, https://doi.org/10.1038/nature11986) influenced him by highlighting the intersection between metabolism and the host response to infectious diseases.

Keywords: immunity; inflammation; metabolic modeling.

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Comment on

  • Succinate is an inflammatory signal that induces IL-1β through HIF-1α.
    Tannahill GM, Curtis AM, Adamik J, Palsson-McDermott EM, McGettrick AF, Goel G, Frezza C, Bernard NJ, Kelly B, Foley NH, Zheng L, Gardet A, Tong Z, Jany SS, Corr SC, Haneklaus M, Caffrey BE, Pierce K, Walmsley S, Beasley FC, Cummins E, Nizet V, Whyte M, Taylor CT, Lin H, Masters SL, Gottlieb E, Kelly VP, Clish C, Auron PE, Xavier RJ, O'Neill LA. Tannahill GM, et al. Nature. 2013 Apr 11;496(7444):238-42. doi: 10.1038/nature11986. Epub 2013 Mar 24. Nature. 2013. PMID: 23535595 Free PMC article.

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