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Meta-Analysis
. 2021 Jul 9;100(27):e26535.
doi: 10.1097/MD.0000000000026535.

Clinicopathological and prognostic significance of long non-coding RNA-ROR in cancer patients: A systematic review and meta-analysis

Deqing Luo  1 , Limin Yang  2 , Le Yu  2 , Yijin Chen  2 , Zunxian Huang  3 , Hui Liu  1
Affiliations
Meta-Analysis

Clinicopathological and prognostic significance of long non-coding RNA-ROR in cancer patients: A systematic review and meta-analysis

Deqing Luo et al. Medicine (Baltimore). .

Abstract

Background: Accumulating studies have focused on the clinicopathological and prognostic roles of large intergenic noncoding RNA regulator of reprogramming (lincRNA-ROR) in cancer patients. However, the results were controversial and unconvincing. Thus, we performed a meta-analysis to assess the associations between lincRNA-ROR expression and survival and clinicopathological characteristics of cancer patients.

Methods: Hazard ratios for overall survival and disease-free survival with their 95% confidence intervals were used to evaluate the role of lincRNA-ROR expression in the prognosis of cancer patients. Risk ratios with their 95% confidence intervals were applied to assess the relationship between lincRNA-ROR expression and clinicopathological parameters.

Results: A total of 18 articles with 1441 patients were enrolled. Our results indicated that high lincRNA-ROR expression was significant associated with tumor size, TNM stage, clinical stage, lymph metastasis, metastasis and vessel invasion of cancer patients. There were no correlations between high lincRNA-ROR expression and age, gender, infiltration depth, differentiation, serum CA19-9 and serum CEA of cancer patients. In addition, high lincRNA-ROR expression was associated with shorter Overall survival and disease-free survival on both univariate and multivariate analyses. Meanwhile, there were no obvious publication bias in our meta-analysis.

Conclusions: LincRNA-ROR expression was associated with the clinicopathological features and outcome of cancer patients, which suggested that lincRNA-ROR might serve as a potential biomarker for cancer prognosis.

Ethical approval: Since this study is on the basis of published articles, ethical approval and informed consent of patients are not required.

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Conflict of interest statement

The authors have no conflicts of interest to disclose.

Figures

Figure 1
Figure 1
Flow chart of study selection.
Figure 2
Figure 2
Forest plots of studies evaluating the association between lncRNA-ROR expression and clinicopathological features including tumor size (A), TNM stage (B), clinical stage (C), lymph metastasis (D), metastasis (E), and vessel invasion (F).
Figure 3
Figure 3
Forest plots of studies evaluating the association between lncRNA-ROR expression and OS with univariate (A) and multivariate analyses (B).
Figure 4
Figure 4
Forest plots of studies evaluating the association between lncRNA-ROR expression and DFS with univariate (A) and multivariate analyses (B).
Figure 5
Figure 5
Galbraith plots of studies evaluating the associations between lncRNA-ROR expression and prognosis including OS with univariate (A) and multivariate (B) analyses, and DFS with univariate (C) and multivariate (D) analyses.
Figure 6
Figure 6
Sensitivity analysis of studies evaluating the associations between lncRNA-ROR expression and prognosis including OS with univariate (A) and multivariate (B) analyses, and DFS with univariate (C) and multivariate (D) analyses.
See this image and copyright information in PMC

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References

    1. Tsai MC, Spitale RC, Chang HY. Long intergenic noncoding RNAs: new links in cancer progression. Cancer Res 2011;71:03–7. - PMC - PubMed
    1. Esteller M. Non-coding RNAs in human disease. Nat Rev Genet 2011;12:861–74. - PubMed
    1. Maruyama R, Suzuki H. Long noncoding RNA involvement in cancer. BMB Rep 2012;45:604–11. - PMC - PubMed
    1. Amaral PP, Clark MB, Gascoigne DK, Dinger ME, Mattick JS. lncRNAdb: a reference database for long noncoding RNAs. Nucleic Acids Res 2011;39:D146–51. - PMC - PubMed
    1. Loewer S, Cabili MN, Guttman M, et al. . Large intergenic non-coding RNA-RoR modulates reprogramming of human induced pluripotent stem cells. Nat Genet 2010;42:1113–7. - PMC - PubMed