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. 2021 Jul 9;100(27):e26555.
doi: 10.1097/MD.0000000000026555.

Prognostic values of procalcitonin and platelet in the patient with urosepsis

Ling Jiang  1 , Shao-Hua Lin  2 , Jun Wang  3 , Cun-Kun Chu  4
Affiliations

Prognostic values of procalcitonin and platelet in the patient with urosepsis

Ling Jiang et al. Medicine (Baltimore). .

Abstract

Background: The patient suffering from urinary sepsis is often accompanied by elevated serum procalcitonin (PCT) levels and a decline in the average platelet count (PLT), which could result in a poor prognosis. This study aimed to evaluate the value of PCT and PLT in determining the severity of urinary sepsis.

Methods: A total of 120 urosepsis patients enrolled were divided into a survival group and a death group, respectively, according to their status within 14 days after admission. Changes in PCT and PLT levels between the 2 groups were compared at different time points. A receiver operating characteristic (ROC) curve was eventually obtained to predict the prognostic value of PCT and PLT.

Results: The PCT levels in the survival group declined gradually after admission, and the PLT decreased at first but increased rapidly in subsequence. The PCT level in the death group, however, declined in a flat-slope trend or was hardly noticeable together with the number of PLT reduced significantly. In particular, it is on the 3rd day that PCT tended to positively correlate with acute physiological and chronic health score II (APACHE II) score (r = 0.730, P < .05), but negatively with PLT (r = 0.472, P < .05). The APACHE II score and PLT (r = 0.612, P < .05) were also negatively correlated with each other. As indicated by the ROC curve, the PCT level on the 3rd day after admission was of great value for the clinical mortality prognosis, and the area under the curve was 0.858. Moreover, PLT also has a high predictive value for prognosis. Area under the curve is 0.951. When the PLT was more than 51 × 109 /L, the sensitivity was up to 90%, and the specificity was 90%.

Conclusion: PLT and PCT levels are closely related to the APACHE II score, which could indicate the severity of urosepsis in patients. The contribution of this study was to confirm that dynamic monitoring of the changes in PCT and PLT helps determine the prognosis of urosepsis patients.

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Conflict of interest statement

The authors have no conflicts of interest to disclose.

Figures

Figure 1
Figure 1
The scatter plot shows that the correlation between serum procalcitonin, the average platelet count, and APACHE II score. PCT was positively correlated with the APACHE II score (r = 0.730, P < .05) (A), and negatively correlated with PLT (r = 0.472, P < .05) (C). It has a negative correlation between APACHE II score and PLT (r = 0.612, P < .05) (B). APACHE II = acute physiological and chronic health score II, PCT = serum procalcitonin, PLT = the average platelet count.
Figure 2
Figure 2
The ROC curve showed the prognostic value of PCT and PLT on the 3rd day after admission. PLT = the average platelet count, PCT = serum procalcitonin, ROC = receiver operating characteristic.
See this image and copyright information in PMC

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