Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Comment
. 2021 Aug;78(2):555-558.
doi: 10.1161/HYPERTENSIONAHA.121.17356. Epub 2021 Jul 7.

Missing Verification of Source Data in Hypertension Research: The HYGIA PROJECT in Perspective

Affiliations
Comment

Missing Verification of Source Data in Hypertension Research: The HYGIA PROJECT in Perspective

Mattias Brunström et al. Hypertension. 2021 Aug.
No abstract available

Keywords: antihypertensive agents; article retraction; blood pressure; chronotherapy; drug therapy.

PubMed Disclaimer

Figures

Figure.
Figure.
Schematic summary of the HYGIA Project; reported results of bedtime dosing of ≥1 antihypertensive drugs, previous knowledge regarding bedtime dosing, review of the outcome by the European Society of Cardiology Journal Ethics Committee, problems and questions related to the project, and the conclusion of this commentary. BP indicates blood pressure; and CV, cardiovascular.

Comment on

References

    1. Hermida RC, Crespo JJ, Dominguez-Sardina M, Otero A, Moyá A, Ríos MT, Sineiro E, Castiñeira MC, Callejas PA, Pousa L, et al. . Bedtime hypertension treatment improves cardiovascular risk reduction: the Hygia Chronotherapy Trial. Eur Heart J. 2020;41:4565–4576. doi: 10.1093/eurheartj/ehz754 - PubMed
    1. Retracted: Primary prevention of cardiovascular disease with a Mediterranean diet. N Engl J Med. 2013;368:1279–1290. doi: 10.1056/NEJMoa1200303 - PubMed
    1. Estruch R, Ros E, Salas-Salvadó J, Covas M-I, Corella D, Arós F, Gómez-Gracia E, Ruiz-Gutiérrez V, Fiol M, Lapetra J, et al. ; PREDIMED Study Investigators. Primary prevention of cardiovascular disease with a Mediterranean diet supplemented with extra-virgin olive oil or nuts. N Engl J Med. 2018;378:e34. doi: 10.1056/NEJMoa1800389 - PubMed
    1. Retracted: Relationship between clinic and ambulatory blood-pressure measurements and mortality. N Engl J Med. 2018;378:1509–1520. doi: 10.1056/NEJMoa1712231 - PubMed
    1. Letter to the Editor. N Engl J Med. 2020;382:786. doi: 10.1056/NEJMc2001445