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Case Reports
. 2022 Jan 1;33(1):91-93.
doi: 10.1097/CAD.0000000000001126.

High grade neuroendocrine carcinoma of the breast, first line and maintenance immunotherapy

David Symeonidis  1 , Georgios Papageorgiou  1 , Alexandros Liatsos  2 , Helen Trihia  3 , Evangelos Lianos  4 , Christos Kosmas  5
Affiliations
Case Reports

High grade neuroendocrine carcinoma of the breast, first line and maintenance immunotherapy

David Symeonidis et al. Anticancer Drugs. .

Abstract

Small cell carcinomas (SCCs) are poorly differentiated neuroendocrine tumors that arise predominantly in the lung and gastrointestinal tract (GIT). Neuroendocrine carcinomas can occur in a variety of extrapulmonary sites throughout the body, including breast, larynx, GIT, prostate, urinary bladder, ovary and cervix. This is a case report of a 55-year-old Asian female patient with metastatic high-grade neuroendocrine carcinoma of unknown origin that responded notably to off-label nivolumab maintenance treatment after first-line carboplatin - etoposide chemotherapy and radiation. After 2 years of nivolumab after platinum-based chemotherapy results from PET-CT showed no residual disease and we proceeded to mastectomy.

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References

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