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. 2022 Jan;52(1):e13649.
doi: 10.1111/eci.13649. Epub 2021 Jul 13.

Omega-3 fatty acids in adipose tissue and risk of atrial fibrillation

Thomas Andersen Rix  1 , Pia Dinesen  1 , Søren Lundbye-Christensen  1   2   3 , Albert Marni Joensen  1   2 , Sam Riahi  1   2 , Kim Overvad  1   4 , Erik Berg Schmidt  1   2
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Omega-3 fatty acids in adipose tissue and risk of atrial fibrillation

Thomas Andersen Rix et al. Eur J Clin Invest. 2022 Jan.

Abstract

Background: The aim of the present study was to examine the relation between adipose tissue content of eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) and the risk of incident atrial fibrillation (AF).

Methods: In this case-cohort study based on data from the Danish Diet, Cancer and Health cohort, a total of 5255 incident cases of AF was identified during 16.9 years of follow-up. Adipose tissue biopsies collected at baseline from all cases and from a randomly drawn subcohort of 3440 participants were determined by gas chromatography. Data were analysed using weighted Cox regression.

Results: Data were available for 4741 incident cases of AF (2920 men and 1821 women). Participants in the highest vs. the lowest quintile of EPA experienced a 45% lower risk of AF (men HR 0.55 (95% CI 0.41-0.69); women HR 0.55 (0.41-0.72)). For DHA, no clear association was found in men, whereas in women, participants in the highest quintile of DHA in adipose tissue had a 30% lower risk of incident AF (HR 0.70 (0.54-0.91)) compared to participants in the lowest quintile.

Conclusions: A monotonous inverse association was found for the content of EPA in adipose tissue and risk of AF in both men and women. The content of DHA was inversely associated with the risk of AF in women, whereas no clear association was found for men.

Keywords: adipose tissue; atrial fibrillation; docosahexaenoic acid; eicosapentaenoic acid; fish oils; n-3 fatty acids.

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References

REFERENCES

    1. Camm AJ, Kirchhof P, Lip GYH, et al. Guidelines for the management of atrial fibrillation: the task force for the management of atrial fibrillation of the European society of cardiology (ESC). Eur Heart J. 2010;31(19):2369-2429. https://doi.org/10.1093/eurheartj/ehq278
    1. Rix TA, Mortensen LM, Schmidt EB. Fish, marine n-3 fatty acids, and atrial fibrillation - experimental data and clinical effects. Front Physiol. 2012;3:152.
    1. Mozaffarian D, Psaty BM, Rimm EB, et al. Fish intake and risk of incident atrial fibrillation. Circulation. 2004;110(4):368-373.
    1. Larsson SC, Wolk A. Fish, long-chain omega-3 polyunsaturated fatty acid intake and incidence of atrial fibrillation: a pooled analysis of two prospective studies. Clin Nutr. 2017;36(2):537-541.
    1. Wu JH, Lemaitre RN, King IB, et al. Association of plasma phospholipid long-chain omega-3 fatty acids with incident atrial fibrillation in older adults: the cardiovascular health study. Circulation. 2012;125(9):1084-1093.

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