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Comment
. 2021 Jul 6;33(7):1276-1278.
doi: 10.1016/j.cmet.2021.06.009.

Protective succinate-SUCNR1 metabolic stress signaling gone bad

Sally Winther  1 , Mette Trauelsen  1 , Thue W Schwartz  2
Affiliations
Free article
Comment

Protective succinate-SUCNR1 metabolic stress signaling gone bad

Sally Winther et al. Cell Metab. .
Free article

Abstract

The TCA cycle metabolite succinate functions as an intra- and extracellular signal of metabolic stress. Based on the phenotype of UCP-1-deficient mice, Mills et al. (2021) now report in Nature Metabolism that accumulation of extracellular succinate due to impaired elimination in thermogenic fat drives liver inflammation and fibrosis through the succinate receptor SUCNR1.

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Conflict of interest statement

Declaration of interests T.W.S. is co-founder and Chief Scientific Godfather of Embark Biotech.

Comment on

  • UCP1 governs liver extracellular succinate and inflammatory pathogenesis.
    Mills EL, Harmon C, Jedrychowski MP, Xiao H, Garrity R, Tran NV, Bradshaw GA, Fu A, Szpyt J, Reddy A, Prendeville H, Danial NN, Gygi SP, Lynch L, Chouchani ET. Mills EL, et al. Nat Metab. 2021 May;3(5):604-617. doi: 10.1038/s42255-021-00389-5. Epub 2021 May 17. Nat Metab. 2021. PMID: 34002097 Free PMC article. Review.

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