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. 2021 Oct 1;50(7):20200384.
doi: 10.1259/dmfr.20200384. Epub 2021 Jul 8.

Primary clinical study of radiomics for diagnosing simple bone cyst of the jaw

Zhe-Yi Jiang  1   2 , Tian-Jun Lan  1   2 , Wei-Xin Cai  1   2 , Qian Tao  1   2
Affiliations

Primary clinical study of radiomics for diagnosing simple bone cyst of the jaw

Zhe-Yi Jiang et al. Dentomaxillofac Radiol. .

Abstract

Objective: To screen the radiomic features of simple bone cysts of the jaws and explore the potential application of radiomics in pre-operative diagnosis of jaw simple bone cysts.

Methods: The investigators designed and implemented a case-control study. 19 patients with simple bone cysts who were admitted to the Department of Maxillofacial Surgery, Sun Yat-sen University Affiliated Stomatology Hospital from 2013 to 2019 were included in this study. Their clinical data and cone-beam computed tomography (CBCT) images were examined. The control group consisted of patients with odontogenic keratocyst. CBCT imaging features were analyzed and compared between the patient and control groups.

Results: Overall, 10,323 image features were extracted through feature analysis. A subset of 25 radiomic features obtained after feature selection were analyzed further. These 25 features were significantly different between the 2 groups (p < 0.05). The absolute value of correlation coefficient was 0.487-0.775. Gray-level co-occurrence matrix (GLCM) contrast, neighborhood gray tone difference matrix (NGTDM) contrast, and GLCM variance were the features with the highest correlation coefficients.

Conclusions: Pre-operative radiomics analysis showed the differences between simple bone cysts and odontogenic keratocysts, can help to diagnose simple bone cysts. Three specific texture features-GLCM contrast, NGTDM contrast, and GLCM variance-may be the characteristic imaging features of simple bone cysts of the jaw.

Keywords: Cone-beam computed tomography; Diagnosis; Odontogenic keratocyst; Radiomics; Simple bone cyst.

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Figures

Figure 1.
Figure 1.
ROI segmentation results from CBCT images. (A) A ROI was manually outlined from CBCT, (B) Axial plane, (C) sagittal plane and (D) coronal plane. The cyst is marked in red. CBCT, cone-beam computed tomography; ROI, region of interest.
Figure 2.
Figure 2.
Panoramic radiograph revealing the scalloping at the root of 47 (arrow).
Figure 3.
Figure 3.
CBCT manifestation of simple bone cyst. (A) A CBCT scan showed only a thinning cortical bone between simple bone cyst and mandibular canal, (B) A CBCT scan showed a bony ridge protruding into the lumen at the edge of the cyst wall. CBCT, cone-beam computed tomography.
Figure 4.
Figure 4.
CBCT manifestation of OKC. A CBCT scan showed part of the bone around the mandibular canal is destroyed by the cyst. (A) sagittal plane, (B) coronal plane, (C) Axial plane. CBCT, cone-beam computed tomography; OKC, odontogenic keratocyst.
See this image and copyright information in PMC

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