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. 2021 Jul 7;25(1):237.
doi: 10.1186/s13054-021-03664-9.

The chicken or the egg: low testosterone predisposes for COVID-19 or COVID-19 induces a decrease in testosterone?

Roeland F Stolk  1   2 , Henk J van Leeuwen  3   4 , Matthijs Kox  1   2 , Marcel van Borren  5 , Hans de Boer  4 , Peter Pickkers  6   7
Affiliations

The chicken or the egg: low testosterone predisposes for COVID-19 or COVID-19 induces a decrease in testosterone?

Roeland F Stolk et al. Crit Care. .
No abstract available

PubMed Disclaimer

Conflict of interest statement

None declared.

Figures

Fig. 1
Fig. 1
Cytokine, steroid and gonadotropin levels over time during human endotoxemia. Levels of circulating TNF-α, IL-6 and IL-10 (A), cortisol, testosterone and estradiol (B) and LH and FSH (C) over time, during human endotoxemia, after LPS administration in healthy volunteers. Data are presented as medians and IQR. LPS-induced changes over time were analyzed using the Friedman test) for all timepoints. IL interleukin, LH luteinizing hormone, FSH follicle stimulating hormone,
See this image and copyright information in PMC

References

    1. Dhindsa S, Zhang N, McPhaul MJ, Wu Z, Ghoshal AK, Erlich EC, et al. Association of circulating sex hormones with inflammation and disease severity in patients with COVID-19. JAMA Netw Open. 2021;4(5):e2111398. doi: 10.1001/jamanetworkopen.2021.11398. - DOI - PMC - PubMed
    1. van Lier D, Geven C, Leijte GP, Pickkers P. Experimental human endotoxemia as a model of systemic inflammation. Biochimie. 2019;159:99–106. doi: 10.1016/j.biochi.2018.06.014. - DOI - PubMed