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Comment
. 2021 Jul 7;6(1):259.
doi: 10.1038/s41392-021-00681-6.

Catch-as-catch-can: mRNA vaccination boosts immune responses to SARS-CoV-2 variants

Graham Pawelec  1   2 , Emilie Picard  3
Affiliations
Comment

Catch-as-catch-can: mRNA vaccination boosts immune responses to SARS-CoV-2 variants

Graham Pawelec et al. Signal Transduct Target Ther. .
No abstract available

PubMed Disclaimer

Conflict of interest statement

The authors declare no competing interests.

Figures

Fig. 1
Fig. 1
Immune responses to SARS-CoV-2 variants are elicited following mRNA vaccination and are further increased in previously SARS-CoV-2-infected and recovered individuals after vaccination. Neutralizing antibody titers against Wuhan-Hu-1 and B.1.351 along with the frequency of spike-specific CD4+ T cells are greatly enhanced in previously SARS-CoV-2-infected individuals subsequent to mRNA vaccination. Neutralizing antibody titers against both the Wuhan-Hu-1 vaccine antigen and the B.1.351 variant are higher than in SARS-CoV-2-naive individuals who received either Pfizer/BioNTech BNT16b2 or Moderna mRNA-1273 vaccine, while an equally high level of spike-specific CD4+ T cells is detected in both vaccinated groups. Overall, neutralizing antibodies against B.1.351 variants are present but at lower titers than against Wuhan-Hu-1 variants in all groups of individuals regardless of vaccination
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References

    1. Stamatatos L, et al. mRNA vaccination boosts cross-variant neutralizing antibodies elicited by SARS-CoV-2 infection. Science. 2021;372:1413–1418. doi: 10.1126/science.abg917. - DOI - PMC - PubMed
    1. McMahan K, et al. Correlates of protection against SARS-CoV-2 in rhesus macaques. Nature. 2021;590:630–634. doi: 10.1038/s41586-020-03041-6. - DOI - PMC - PubMed
    1. Jarjour NN, Masopust D, Jameson SC. T cell memory: understanding COVID-19. Immunity. 2021;54:14–18. doi: 10.1016/j.immuni.2020.12.009. - DOI - PMC - PubMed
    1. McElhaney JE, et al. Granzyme B: correlates with protection and enhanced CTL response to influenza vaccination in older adults. Vaccine. 2009;27:2418–2425. doi: 10.1016/j.vaccine.2009.01.136. - DOI - PMC - PubMed
    1. Chen Y, et al. Aging in COVID-19: vulnerability, immunity and intervention. Ageing Res. Rev. 2021;65:101205. doi: 10.1016/j.arr.2020.101205. - DOI - PMC - PubMed