Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Comment
. 2021 Jul 7;6(1):258.
doi: 10.1038/s41392-021-00683-4.

RNA methylation preserves ES cell identity by chromatin silencing of retrotransposons

Zhaofa Xu  1 , Annabel Ma  1 , Yongchao C Ma  2
Affiliations
Comment

RNA methylation preserves ES cell identity by chromatin silencing of retrotransposons

Zhaofa Xu et al. Signal Transduct Target Ther. .
No abstract available

PubMed Disclaimer

Conflict of interest statement

The authors declare no competing interests.

Figures

Fig. 1
Fig. 1
Working model for the mechanism underlying m6A and YTHDC1-mediated maintenance of embryonic stem cell identity through chromatin silencing. Methylation of retrotransposon RNA recruits m6A reader YTHDC1 and H3K9me3 methyltransferase SETDB1 to promote retrotransposon chromatin silencing, which represses two-cell-like state transition, leading to embryonic stem cell identity maintenance
See this image and copyright information in PMC

Comment on

References

    1. Liu J, et al. The RNA m(6)A reader YTHDC1 silences retrotransposons and guards ES cell identity. Nature. 2021;591:322–326. doi: 10.1038/s41586-021-03313-9. - DOI - PubMed
    1. Lu F, Zhang Y. Cell totipotency: molecular features, induction, and maintenance. Natl Sci. Rev. 2015;2:217–225. doi: 10.1093/nsr/nwv009. - DOI - PMC - PubMed
    1. Jiang X, et al. The role of m6A modification in the biological functions and diseases. Sig. Transduct. Target. Ther. 2021;6:74. doi: 10.1038/s41392-020-00450-x. - DOI - PMC - PubMed
    1. Wang J, et al. Leukemogenic chromatin alterations promote AML leukemia stem cells via a KDM4C-ALKBH5-AXL signaling axis. Cell Stem Cell. 2020;27:81–97.e88. doi: 10.1016/j.stem.2020.04.001. - DOI - PubMed
    1. Chen C, et al. Nuclear m(6)A reader YTHDC1 regulates the scaffold function of LINE1 RNA in mouse ESCs and early embryos. Protein Cell. 2021;12:455–474. doi: 10.1007/s13238-021-00837-8. - DOI - PMC - PubMed

Publication types