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Comment
. 2021 Jul 7;6(1):257.
doi: 10.1038/s41392-021-00680-7.

Osteolectin+ stromal cells: Mechanical stimulation improves bone regeneration and supports bacterial clearance after fracture

Sabrina Ehnert  1 , Tina Histing  1 , Andreas K Nüssler  2
Affiliations
Comment

Osteolectin+ stromal cells: Mechanical stimulation improves bone regeneration and supports bacterial clearance after fracture

Sabrina Ehnert et al. Signal Transduct Target Ther. .
No abstract available

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Conflict of interest statement

The authors declare no competing interests.

Figures

Fig. 1
Fig. 1
The peri-arteriolar niche is mainly found in the central bone marrow and near the endosteum of diaphyseal bone. In close proximity to the arterioles, the niche harbors highly proliferative, short-lived, stem cell factor (SCF) expressing, leptin receptor (LEPR), and osteolectin (Oln)-positive stromal cells. These cells decrease in number with age and after PTH treatment, but increase in number after fracture and due to mechanical stimulation. A critical regulator for the mechanosensing is the ion channel PIEZO1. The LEPR+Oln+ stromal cells regulate not only new bone formation, but also maintenance and commitment of common lymphoid progentiors and thus, contribute to bacterial clearance after infections
See this image and copyright information in PMC

Comment on

  • A mechanosensitive peri-arteriolar niche for osteogenesis and lymphopoiesis.
    Shen B, Tasdogan A, Ubellacker JM, Zhang J, Nosyreva ED, Du L, Murphy MM, Hu S, Yi Y, Kara N, Liu X, Guela S, Jia Y, Ramesh V, Embree C, Mitchell EC, Zhao YC, Ju LA, Hu Z, Crane GM, Zhao Z, Syeda R, Morrison SJ. Shen B, et al. Nature. 2021 Mar;591(7850):438-444. doi: 10.1038/s41586-021-03298-5. Epub 2021 Feb 24. Nature. 2021. PMID: 33627868 Free PMC article.

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