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Review
. 2021 Jun 21:12:684162.
doi: 10.3389/fphar.2021.684162. eCollection 2021.

Pharmacogenomics of NSAID-Induced Upper Gastrointestinal Toxicity

Affiliations
Review

Pharmacogenomics of NSAID-Induced Upper Gastrointestinal Toxicity

L McEvoy et al. Front Pharmacol. .

Abstract

Non-steroidal anti-inflammatory drugs (NSAIDs) are a group of drugs which are widely used globally for the treatment of pain and inflammation, and in the case of aspirin, for secondary prevention of cardiovascular disease. Chronic non-steroidal anti-inflammatory drug use is associated with potentially serious upper gastrointestinal adverse drug reactions (ADRs) including peptic ulcer disease and gastrointestinal bleeding. A few clinical and genetic predisposing factors have been identified; however, genetic data are contradictory. Further research is needed to identify clinically relevant genetic and non-genetic markers predisposing to NSAID-induced peptic ulceration.

Keywords: NSAID (non-steroidal anti-inflammatory drug); adverse drug reaction; aspirin; gastrointestinal toxicities; pharmacogenomic.

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Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

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