Pharmacogenomics of NSAID-Induced Upper Gastrointestinal Toxicity
- PMID: 34234675
- PMCID: PMC8256335
- DOI: 10.3389/fphar.2021.684162
Pharmacogenomics of NSAID-Induced Upper Gastrointestinal Toxicity
Abstract
Non-steroidal anti-inflammatory drugs (NSAIDs) are a group of drugs which are widely used globally for the treatment of pain and inflammation, and in the case of aspirin, for secondary prevention of cardiovascular disease. Chronic non-steroidal anti-inflammatory drug use is associated with potentially serious upper gastrointestinal adverse drug reactions (ADRs) including peptic ulcer disease and gastrointestinal bleeding. A few clinical and genetic predisposing factors have been identified; however, genetic data are contradictory. Further research is needed to identify clinically relevant genetic and non-genetic markers predisposing to NSAID-induced peptic ulceration.
Keywords: NSAID (non-steroidal anti-inflammatory drug); adverse drug reaction; aspirin; gastrointestinal toxicities; pharmacogenomic.
Copyright © 2021 McEvoy, Carr and Pirmohamed.
Conflict of interest statement
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
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