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. 1977 Sep;18(9):688-91.
doi: 10.1136/gut.18.9.688.

Can hepatic coma be caused by a reduction of brain noradrenaline or dopamine?

L Zieve, R L Olsen

Can hepatic coma be caused by a reduction of brain noradrenaline or dopamine?

L Zieve et al. Gut. 1977 Sep.

Abstract

Intraventricular infusions of octopamine which raised brain octopamine concentrations more than 20 000-fold resulted in reductions in brain noradrenaline and dopamine by as much as 90% without affecting the alertness or activity of normal rats. As this reduction of brain catecholamines is much greater than any reported in hepatic coma, we do not believe that values observed in experimental hepatic failure have aetiological significance for the encephalopathy that ensues.

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