Editorial: metformin for portal hypertension-old dog, new tricks? Authors' reply

Nikolaj Rittig^{1

2}, Niels Kristian Aagaard³, Gerda Elisabeth Villadsen³, Thomas Damgaard Sandahl³, Niels Jessen^{1

4

5}, Henning Grønbaek³, Jacob George⁶

Affiliations

¹ Steno Diabetes Center Aarhus, Aarhus University Hospital, Aarhus, Denmark.
² Department and Laboratories of Diabetes and Hormone diseases, Aarhus University Hospital, Aarhus, Denmark.
³ Department of Hepatology & Gastroenterology, Aarhus University Hospital, Aarhus, Denmark.
⁴ Department of Clinical Pharmacology, Aarhus University Hospital, Aarhus, Denmark.
⁵ Research Laboratories for Biochemical Pathology, Aarhus University Hospital, Aarhus, Denmark.
⁶ Storr Liver Centre, Westmead Institute for Medical Research, Westmead Hospital and University of Sydney, Westmead, NSW, Australia.

Editorial

Nikolaj Rittig et al. Aliment Pharmacol Ther. 2021 Aug.

. 2021 Aug;54(3):347.

doi: 10.1111/apt.16503.

Nikolaj Rittig^{1

2}, Niels Kristian Aagaard³, Gerda Elisabeth Villadsen³, Thomas Damgaard Sandahl³, Niels Jessen^{1

4

5}, Henning Grønbaek³, Jacob George⁶

¹ Steno Diabetes Center Aarhus, Aarhus University Hospital, Aarhus, Denmark.
² Department and Laboratories of Diabetes and Hormone diseases, Aarhus University Hospital, Aarhus, Denmark.
³ Department of Hepatology & Gastroenterology, Aarhus University Hospital, Aarhus, Denmark.
⁴ Department of Clinical Pharmacology, Aarhus University Hospital, Aarhus, Denmark.
⁵ Research Laboratories for Biochemical Pathology, Aarhus University Hospital, Aarhus, Denmark.
⁶ Storr Liver Centre, Westmead Institute for Medical Research, Westmead Hospital and University of Sydney, Westmead, NSW, Australia.

No abstract available

Comment on

Randomised clinical study: acute effects of metformin versus placebo on portal pressure in patients with cirrhosis and portal hypertension.
Rittig N, Aagaard NK, Villadsen GE, Sandahl TD, Jessen N, Grønbaek H, George J. Rittig N, et al. Aliment Pharmacol Ther. 2021 Aug;54(3):320-328. doi: 10.1111/apt.16460. Epub 2021 Jun 24. Aliment Pharmacol Ther. 2021. PMID: 34165199 Clinical Trial.
Editorial: metformin for portal hypertension-old dog, new tricks?
Palaniyappan N, Fallowfield JA. Palaniyappan N, et al. Aliment Pharmacol Ther. 2021 Aug;54(3):345-346. doi: 10.1111/apt.16484. Aliment Pharmacol Ther. 2021. PMID: 34236093 No abstract available.

1. Palaniyappan N, Fallowfield JA. Editorial: metformin for portal hypertension - old dog, new tricks? Aliment Pharmacol Ther. 2021;54:345-346.
1. Rittig N, Aagaard NK, Villadsen GE, et al. Randomised clinical study: acute effects of metformin versus placebo on portal pressure in patients with cirrhosis and portal hypertension. Aliment Pharmacol Ther. 2021;54:320-328.
1. Tripathi DM, Erice E, Lafoz E, et al. Metformin reduces hepatic resistance and portal pressure in cirrhotic rats. Am J Physiol Gastrointest Liver Physiol. 2015;309:G301-G309.
1. Sundelin E, Jensen JB, Jakobsen S, Gormsen LC, Jessen N. Metformin biodistribution, a key to mechanisms of action? J Clin Endocrinol Metab. 2020;105:3374-3383.