Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2021:2361:229-248.
doi: 10.1007/978-1-0716-1641-3_14.

Databases for Protein-Protein Interactions

Affiliations
Review

Databases for Protein-Protein Interactions

Natsu Nakajima et al. Methods Mol Biol. 2021.

Abstract

Protein-protein interaction networks have a crucial role in biological processes. Proteins perform multiple functions in forming physical and functional interactions in cellular systems. Information concerning an enormous number of protein interactions in a wide range of species has accumulated and has been integrated into various resources for molecular biology and systems biology. This chapter provides a review of the representative databases and the major computational methods used for protein-protein interactions.

Keywords: Computational methods; Molecular interactions; Protein interaction networks; Protein structures; Protein–protein interactions.

PubMed Disclaimer

References

    1. Licata L, Briganti L, Peluso D et al (2012) MINT, the molecular interaction database: 2012 update. Nucleic Acids Res 40:D857–D861 - PubMed
    1. Szklarczyk D, Gable AL, Lyon D et al (2019) STRING v11: protein–protein association networks with increased coverage, supporting functional discovery in genome-wide experimental datasets. Nucleic Acids Res 47:D607–D613
    1. Oughtred R, Stark C, Breitkreutz BJ et al (2019) The BioGRID interaction database: 2019 update. Nucleic Acids Res 47:D529–D541 - PubMed
    1. Kerrien S, Aranda B, Breuza L et al (2012) The IntAct molecular interaction database in 2012. Nucleic Acids Res 40:D841–D846 - PubMed
    1. Salwinski L, Miller CS, Smith AJ et al (2004) The database of interacting proteins: 2004 update. Nucleic Acids Res 32:D449–D451 - PubMed - PMC

Publication types

LinkOut - more resources