Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2021 Oct;21(10):3421-3427.
doi: 10.1111/ajt.16752. Epub 2021 Jul 19.

Single-stage long-segment tracheal transplantation

Eric M Genden  1   2 , Brett A Miles  1 , Timothy J Harkin  3   4 , Samuel DeMaria  5 , Andrew J Kaufman  4 , Erica Mayland  1 , Vivian F Kaul  1 , Sander S Florman  2   6
Affiliations
Free article

Single-stage long-segment tracheal transplantation

Eric M Genden et al. Am J Transplant. 2021 Oct.
Free article

Abstract

Tracheal transplantation has been envisioned as a viable option for reconstruction of long-segment tracheal defects. We report the first human single-stage long-segment tracheal transplantation. Narrow-band imaging and bronchoscopic biopsies demonstrate allograft vascularization and viable epithelial lining. The recipient was immunosuppressed with Tacrolimus, Mycophenolate mofetil, and corticosteroids. Six months after transplantation, the trachea is both functional and the patient is breathing without the need of a tracheostomy or stent.

Keywords: clinical research/practice; organ procurement; surgical technique; vascularized composite and reconstructive transplantation.

PubMed Disclaimer

Comment in

References

REFERENCES

    1. Miura T, Grillo HC. The contribution of the inferior thyroid artery to the blood supply of the human trachea. Surg Gynecol Obstet. 1966;123(1):99-102.
    1. Rose KG, Sesterhenn K, Wustrow F. Tracheal allotransplantation in man. Lancet. 1979;1(8113):433.
    1. Delaere P, Lerut T, Van Raemdonck D. Tracheal transplantation: state of the art and key role of blood supply in its success. Thorac Surg Clin. 2018;28(3):337-345.
    1. Genden EM, Govindaraj S. Allograft tracheoplasty technique for management of refractory tracheal stenosis. Ann Otol Rhinol Laryngol. 2006;115(4):302-305.
    1. Ernst A, Ashiku S. Tracheal transplantation: are we any closer to the Holy Grail of airway management? Chest. 2006;130(5):1299-1300.

Substances