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. 2021 Jul 8;11(1):14122.
doi: 10.1038/s41598-021-93728-1.

Relationship between serum total testosterone and prostate volume in aging men

Bo-Wen Xia  1 , Si-Cong Zhao  1 , Zong-Ping Chen  1 , Chao Chen  1 , Tian-Shu Liu  1 , Fan Yang  1 , Yong Yan  2
Affiliations

Relationship between serum total testosterone and prostate volume in aging men

Bo-Wen Xia et al. Sci Rep. .

Abstract

Total testosterone levels decline with age, while prostate volume and the prevalence of benign prostatic hyperplasia increase with age. We sought to investigate the correlation of serum testosterone levels with prostate volume in aging men. We analyzed clinical data obtained from 416 ostensibly healthy men who underwent routine health check-ups and recruited and collected data from these subjects 4 years later. We analyzed the correlation between prostate volume and relevant factors, as well as the correlation between changes in prostate volume and low testosterone over a 4-year period. Men with low testosterone had significantly larger prostate volume than those in the normal testosterone group (26.86 ± 8.75 vs. 24.06 ± 6.77 P = 0.02), and subjects with low testosterone had significantly higher levels of obesity-related factors, including waist circumference, body mass index, and insulin (all P < 0.001). After adjustment for age, testosterone level was negatively correlated with prostate volume (P = 0.004), and prostate volume and 4-year changes in prostate volume were associated with low testosterone. With increased testosterone level, prostate volume showed a significant linear decreasing trend. These findings provide evidence of the relationship between testosterone and prostate volume. Additional large studies are needed to confirm these preliminary results.

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Conflict of interest statement

The authors declare no competing interests.

Figures

Figure 1
Figure 1
Flow chart of selection of the included subjects.
Figure 2
Figure 2
Mean prostate volume and prostate volume after 4 years adjusted for age. White circle indicates mean. Lower and upper bar indicates 95% CI.
See this image and copyright information in PMC

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