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Meta-Analysis
. 2021 Jun 19:2021:9151525.
doi: 10.1155/2021/9151525. eCollection 2021.

The Epidemiology of Primary Biliary Cholangitis in European Countries: A Systematic Review and Meta-Analysis

Jakub Gazda  1 , Sylvia Drazilova  1 , Martin Janicko  1 , Peter Jarcuska  1
Affiliations
Meta-Analysis

The Epidemiology of Primary Biliary Cholangitis in European Countries: A Systematic Review and Meta-Analysis

Jakub Gazda et al. Can J Gastroenterol Hepatol. .

Abstract

Background: Primary biliary cholangitis (PBC) is a chronic autoimmune cholestatic liver disease with wide ranges of reported incidence and prevalence.

Aim: To map the incidence and prevalence of PBC in European countries from 2000 through 2020.

Methods: Following PRISMA recommendations, we searched the Medline and Scopus databases for studies with information on either the incidence or prevalence of PBC. After data extraction, we used a random-effects model to estimate both the pooled annual incidence rate and pooled point-prevalence rate and performed subgroup analyses to identify components contributing to between-study heterogeneity.

Results: We performed a qualitative and quantitative analysis of 18 studies. The pooled point-prevalence rate was 22.27 cases per 100,000 inhabitants (95% CI: 17.98-27.01), and the pooled annual incidence rate was 1.87 new cases per 100,000 inhabitants (95% CI: 1.46-2.34). In the subgroup analyses, we proved that a small part of the between-study heterogeneity is significantly associated with a history of being part of the Eastern Bloc.

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Conflict of interest statement

The authors declare that they have no conflicts of interest.

Figures

Figure 1
Figure 1
Flowchart of studies inclusion.
Figure 2
Figure 2
Choropleth map of PBC point-prevalence rates in Europe.
Figure 3
Figure 3
PBC point-prevalence rates in Europe.
Figure 4
Figure 4
Funnel plot of PBC point-prevalence rates in Europe.
Figure 5
Figure 5
Subgroup analyses of PBC point-prevalence rates. (a) Diagnostic criteria. (b) Case-finding methods. (c) Underlying population. (d) Former Eastern/Western Bloc.
Figure 6
Figure 6
(a) Female PBC point-prevalence rates in Europe. (b) Male PBC point-prevalence rates in Europe.
Figure 7
Figure 7
Choropleth map of annual PBC incidence rates in Europe.
Figure 8
Figure 8
Annual PBC incidence rates in Europe.
Figure 9
Figure 9
Funnel plot of annual PBC incidence rates in Europe.
Figure 10
Figure 10
Subgroup analyses of annual PBC incidence rates. (a) Diagnostic criteria. (b) Case-finding methods. (c) Underlying population. (d) Former Eastern/Western Bloc.
Figure 11
Figure 11
(a) Annual female PBC incidence rates in Europe. (b) Annual male PBC incidence rates in Europe.
See this image and copyright information in PMC

References

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