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. 1978 Feb;34(2):337-45.

Differential tolerance of thymus-independent and thymus-dependent antibody responses

J P Tite, S Marshall-Clarke, J H Playfair

Differential tolerance of thymus-independent and thymus-dependent antibody responses

J P Tite et al. Immunology. 1978 Feb.

Abstract

The effect of pre-immunization with soluble haptenated serum proteins or haptenated carbohydrates on the subsequent responses to the hapten in thymus-dependent or thymus-independent form was investigated. In certain cases both thymus-dependent and -independent responses were suppressed whilst in others a differential suppression of thymus-independent responsiveness was observed. These results are discussed in terms of B-cell subpopulations and mechanisms of tolerance induction.

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References

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