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. 2021 Aug;41(8):796-799.
doi: 10.1002/cac2.12185. Epub 2021 Jul 9.

Evaluation of renal cancer progression in a mouse model of heart failure

Canxia Shi  1 , Joseph Pierre Aboumsallem  1 , Sanne de Wit  1 , Elisabeth Maria Schouten  1 , Valentina Bracun  1 , Wouter C Meijers  1 , Herman H W Silljé  1 , Rudolf A de Boer  1
Affiliations

Evaluation of renal cancer progression in a mouse model of heart failure

Canxia Shi et al. Cancer Commun (Lond). 2021 Aug.
No abstract available

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Conflict of interest statement

The University Medical Center Groningen (UMCG), which employs the authors, has received research grants and/or fees from AstraZeneca, Abbott, Bristol‐Myers Squibb, Novartis, Novo Nordisk, and Roche. Dr. de Boer received speaker fees from Abbott, AstraZeneca, Bayer, Novartis, and Roche.

Figures

FIGURE 1
FIGURE 1
Evaluation of the effects of heart failure on renal cancer progression. A. Experimental design of orthotopic Renca‐luc implantation model 2 weeks after MI or sham surgery. Echocardiography was acquired 1 and 5 weeks after surgery. Tumor growth was monitored using an IVIS 100 Imaging System on days 1, 7, 14, and 20 respectively post‐tumor implantation. On day 21, the mice were euthanized. B. Luciferase activity of Renca‐luc cells measured by IVIS 100 imaging system. C. Association of bioluminescent signal with Renca‐luc cell numbers determined by linear regression. D. Bioluminescent images demonstrating tumor growth in vivo. E. Left ventricular ejection fraction determined by echocardiography 1 week after surgery. F. Representative heart sections stained with Masson trichome. G. Quantification of cardiac fibrosis from Masson trichrome stained sections. H. Quantification of bioluminescence released by tumor at days 1, 7, 14, and 20 after Renca‐luc cell implantation. I. Tumor weight measured at 5 weeks after surgery. Data are presented as mean ± standard deviation. *** P < 0.001. Abbreviations: MI, myocardial infarction; Echo, echocardiography; Renca‐luc, luciferase‐expressing Renca cell line
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