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. 2021 Aug;25(3):1999-2000.
doi: 10.1007/s11030-021-10272-w. Epub 2021 Jul 9.

Hemagglutinin-esterase cannot be considered as a candidate for designing drug against COVID-19

Milad Zandi  1   2 , Saber Soltani  3   4
Affiliations

Hemagglutinin-esterase cannot be considered as a candidate for designing drug against COVID-19

Milad Zandi et al. Mol Divers. 2021 Aug.

Abstract

We read with interest the article by Patel et al. on the identification of potential inhibitors of coronavirus hemagglutinin-esterase. The authors considered hemagglutinin-esterase as a glycoprotein of SARS-CoV-2 and selected hemagglutinin-esterase as a target to identify potential inhibitors using a combination of various computational approaches, and however, SARS-CoV-2 genome lacks hemagglutinin-esterase gene; thus, hemagglutinin-esterase does not exist in SARS-CoV-2 particle.

Keywords: Betacoronavirus; Genome; Hemagglutinin-esterase; SARS-CoV-2.

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Conflict of interest statement

Authors declare no conflicts of interest.

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