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. 2022 Jan;22(1):24-27.
doi: 10.1111/ajt.16758. Epub 2021 Jul 26.

Antibodies, boosters, and optimizing SARS-CoV-2 vaccines for transplantation: A call for more research

Michael G Ison  1 , Emily Blumberg  2 , Natasha Halasa  3 , Dan Kaul  4 , Nicole M Theodoropoulos  5 , Cameron R Wolfe  6
Affiliations

Antibodies, boosters, and optimizing SARS-CoV-2 vaccines for transplantation: A call for more research

Michael G Ison et al. Am J Transplant. 2022 Jan.

Abstract

Despite emerging data suggesting reduced antibody responses among solid organ transplant recipients following SARS-CoV-2 vaccine, critical unanswered questions remain. The clinical implications of the reduced humoral response need to be assessed through prospective studies. Studies are likewise needed to inform which vaccine dosing strategies result in improved immunity and if such approaches maximize protection against severe infection in the vulnerable transplant population.

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References

    1. US Food and Drug Administration. Antibody testing is not currently recommended to assess immunity after COVID-19 vaccination: FDA safety communication. Accessed July 21, 2021. https://www.fda.gov/medical-devices/safety-communications/antibody-testi....
    1. Schmidt T, Klemis V, Schub D, Schneitler S, Reichert MC, Wilkens H, et al. Cellular immunity predominates over humoral immunity after the first dose of COVID-19 vaccines in solid organ transplant recipients. medRxiv 2021. - PMC - PubMed
    1. Boyarsky BJ, Werbel WA, Avery RK, et al. Antibody response to 2-dose SARS-CoV-2 mRNA vaccine series in solid organ transplant recipients. JAMA. 2021;325(21):2204–2206. - PMC - PubMed
    1. Kamar N, Abravanel F, Marion O, Couat C, Izopet J, Del Bello A. Three doses of an mRNA Covid-19 vaccine in solid-organ transplant recipients. N Engl J Med. [published online ahead of print 2021]. 10.1056/NEJMc2108861. - DOI - PMC - PubMed
    1. Team CC-VBCI COVID-19 vaccine breakthrough infections reported to CDC — United States, January 1–April 30, 2021. Morb Mortal Wkly Rep. 2021;70(21):792–793. - PMC - PubMed