Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2022 Dec 31;18(1):1949953.
doi: 10.1080/21645515.2021.1949953. Epub 2021 Jul 9.

SARS-CoV-2 vaccination in the context of original antigenic sin

Marek Petráš  1 , Ivana Králová Lesná  2   3
Affiliations

SARS-CoV-2 vaccination in the context of original antigenic sin

Marek Petráš et al. Hum Vaccin Immunother. .

Abstract

Immunological memory is the ability of the adaptive immune system to ensure a persistent protective effect after immunization. However, it can also be a limitation to building a sufficient level of protective antibodies specific to new mutations of the virus. It is imperative to bear this phenomenon (called "original antigenic sin") in mind and make every effort to overcome its inherent pitfalls when updating current and designing new vaccines.

Keywords: Original antigenic sin; SARS-COV-2; vaccination.

PubMed Disclaimer

References

    1. JANSSEN BIOTECH, INC . COVID-19 vaccine Ad26.COV2.S VAC31518 (JNJ-78436735). Vaccines and related biological products advisory committee meeting; Meeting date: 2021. February 26. [accessed 2021 March 15]. https://www.fda.gov/media/146219/download.
    1. AstraZeneca . COVID-19 vaccine AstraZeneca. Assessment report. Common name: COVID-19 Vaccine (ChAdOx1-S [recombinant]) Procedure No. EMEA/H/C/005675/0000; [accessed 2021 March 15]. https://www.ema.europa.eu/en/documents/assessment-report/covid-19-vaccin....
    1. Francis T, Davenport FM, Hennessy AV.. A serological recapitulation of human infection with different strains of influenza virus. Trans Assoc Am Physicians. 1953;66:231–3. - PubMed
    1. Vatti A, Monsalve DM, Pacheco Y, Chang C, Anaya JM, Gershwin ME. Original antigenic sin: a comprehensive review. J Autoimmun. 2017;83:12–21. doi:10.1016/j.jaut.2017.04.008. - DOI - PubMed
    1. Centers for Disease Control and Prevention (CDC). Serum cross-reactive antibody response to a novel influenza A (H1N1) virus after vaccination with seasonal influenza vaccine. MMWR Morb Mortal Wkly Rep. 2009; 58:521–24. - PubMed