Biomarkers of laryngeal squamous cell carcinoma: a review

Abstract

Laryngeal carcinoma is the second common malignancy of the upper aerodigestive tract after lung cancer; in most cases is a squamous cell carcinoma, whose risk factors include tobacco smoking and alcohol consumption. Despite therapeutic progress, the five-year overall survival rate for this malignancy has remained nearly 50% and many patients already present metastasis at the time of diagnosis. To date, there are no tools that predict the evolution of laryngeal carcinoma: in this light, during the last years, many studies were planned with the aim to investigate the role played by different biomarkers expressed by larynx cancer, which can help make an early diagnosis, predict disease evolution and direct therapeutic choice. This review aims to summarize these markers and correlating them with disease evolution.

Keywords: Cadherins; Cyclin D1; Focal adhesion protein-tyrosine kinases; Ki-67 antigen; Laryngeal neoplasms; RNA, long noncoding; Receptors, growth factor; Tumour suppressor protein p53.