Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2021 Aug;120(8):2965-2968.
doi: 10.1007/s00436-021-07230-8. Epub 2021 Jul 10.

Plasma cytokines during acute human fascioliasis

Catalina Aron-Said  1 , Martin Montes  1   2 , A Clinton White Jr  3   4 , Miguel M Cabada  1   2
Affiliations

Plasma cytokines during acute human fascioliasis

Catalina Aron-Said et al. Parasitol Res. 2021 Aug.

Abstract

Fascioliasis is a foodborne trematode endemic worldwide. Children under 15 years have the highest prevalence of infection. We hypothesized that acute fascioliasis would be associated with more pronounced cytokine changes than in chronic disease or no helminth infections. To test this hypothesis, 33 children who lived in the Peruvian highlands were classified into 3 groups: acute fascioliasis, chronic fascioliasis, and no helminth infection. Type Th1, Th2, and Th17 cytokines were measured in plasma by cytometric bead array. Children with acute infection had higher levels of IL-5 and IL-17 compared with controls (p < 0.001 and p < 0.007, respectively). The increased IL-5 plasma concentration in children with acute infection was associated with the eosinophilia found in that group.

Keywords: Fasciola; IL-17; IL-5.

PubMed Disclaimer

Conflict of interest statement

Conflicts of Interest/Competing Interests: None

References

    1. Robinson MW, Dalton JP, 2009. Zoonotic helminth infections with particular emphasis on fasciolosis and other trematodiases. Philos Trans R Soc Lond B Biol Sci 364(1530): 2763–2776. - PMC - PubMed
    1. Webb CM, Cabada MM, 2018. Recent developments in the epidemiology, diagnosis, and treatment of Fasciola infection. Curr Opin Infect Dis 31(5): 409–414. - PubMed
    1. Aksoy DY, Kerimoglu U, Oto A, Erguven S, Arslan S, Unal S, Batman F, Bayraktar Y, 2005. Infection with Fasciola hepatica. Clin Microbiol Infect 11(11): 859–861. - PubMed
    1. Marcos Raymundo LA, Maco Flores V, Terashima Iwashita A, Samalvides Cuba F, Gotuzzo Herencia E, 2002. Clinical characteristics of chronic infection by Fasciola hepatica in children. Rev Gastroenterol Peru 22(3): 228–233. - PubMed
    1. Lopez M, White AC Jr, Cabada MM, 2012. Burden of Fasciola hepatica Infection among Children from Paucartambo in Cusco, Peru. Am J Trop Med Hyg 86(3): 481–485. - PMC - PubMed

LinkOut - more resources