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Comment
. 2021 Nov;75(5):1252-1254.
doi: 10.1016/j.jhep.2021.06.044. Epub 2021 Jul 8.

The mRNA COVID-19 vaccine - A rare trigger of autoimmune hepatitis?

Cathy McShane  1 , Clifford Kiat  2 , Jonathan Rigby  3 , Órla Crosbie  2
Affiliations
Comment

The mRNA COVID-19 vaccine - A rare trigger of autoimmune hepatitis?

Cathy McShane et al. J Hepatol. 2021 Nov.
No abstract available

Keywords: Autoimmune Hepatitis; COVID-19 Vaccine; mRNA vaccines.

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Conflict of interest statement

Conflicts of interest The authors declare no conflicts of interest that pertain to this work. Please refer to the accompanying ICMJE disclosure forms for further details.

Figures

Fig. 1
Fig. 1
Histological (H&E stain) and biochemical findings. (A) Marked portal tract (star) inflammation with enlargement and an irregular disrupted interface and a lobular hepatitis (long arrow)(100x). (B) At higher magnification the portal tract inflammation is mononuclear with spill over and damage to the periportal hepatocytes (200x). (C) At high magnification many of the mononuclear inflammatory cells are plasma cells (short arrows). This lymphoplasmacytic infiltrate damages periportal hepatocytes with some forming rosettes (long arrow) and with occasional emperipolesis of lymphocytes (arrowhead)(400x). (D) Trend of ALT, AST and bilirubin following introduction of steroids. ALT, alanine aminotransferase; AST, aspartate aminotransferase. (This figure appears in color on the web.)
See this image and copyright information in PMC

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