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Case Reports
. 2021 Jun 9;14(2):792-796.
doi: 10.1159/000516275. eCollection 2021 May-Aug.

Optic Perineuritis Associated with Nivolumab Treatment for Non-Small Cell Lung Cancer

Kenji Takada  1 , Keiichi Fujiwara  1 , Eri Ando  1 , Kiriko Onishi  1 , Tadahiro Kuribayashi  1 , Sho Mitsumune  1 , Yuki Takigawa  1 , Hiroaki Matsuura  1 , Hiromi Watanabe  1 , Kenichiro Kudo  1 , Akiko Sato  1 , Ken Sato  1 , Takuo Shibayama  1
Affiliations
Case Reports

Optic Perineuritis Associated with Nivolumab Treatment for Non-Small Cell Lung Cancer

Kenji Takada et al. Case Rep Oncol. .

Abstract

We report the case of a 54-year-old man who was treated with nivolumab for recurrent squamous cell lung cancer. After 7 cycles of nivolumab treatment, the patient presented to our hospital with right eye vision loss. Gadolinium-enhanced magnetic resonance imaging of the brain showed enhancement around the optic nerve sheath. This finding and his symptoms led to the diagnosis of optic perineuritis (OPN). Steroid pulse therapy was administered twice although there was no remarkable improvement in his visual field defect. The relationship between OPN and nivolumab is unclear. However, immune-related adverse events caused by immune checkpoint inhibitors should be considered.

Keywords: Immune checkpoint inhibitor; Immune-related adverse events; Nivolumab; Optic perineuritis.

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Conflict of interest statement

The authors state that they have no conflicts of interest.

Figures

Fig. 1
Fig. 1
Goldmann perimetry showing an inferior nasal visual field defect in the right eye.
Fig. 2
Fig. 2
Head gadolinium-enhanced, fat-saturated T2 MRI. a In the axial view, the “tram-tracks” sign of the optic nerve sheath is observed. b In the coronal view, the “doughnut” sign of the optic nerve sheath is observed. MRI, magnetic resonance imaging.
See this image and copyright information in PMC

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