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. 2021 Jun 24:14:17562848211021783.
doi: 10.1177/17562848211021783. eCollection 2021.

Evaluation of the short-term efficacy of local analgesic (lidocaine) and opioid analgesic (sufentanil) on patients with centrally mediated abdominal pain syndrome: a randomized controlled trial

Hang Yang  1 , Honglin Chen  2 , Bing Hu  3
Affiliations

Evaluation of the short-term efficacy of local analgesic (lidocaine) and opioid analgesic (sufentanil) on patients with centrally mediated abdominal pain syndrome: a randomized controlled trial

Hang Yang et al. Therap Adv Gastroenterol. .

Abstract

Background: Centrally mediated abdominal pain syndrome (CAPS) is characterized by continuous or frequently recurring abdominal pain and can result in functional loss across several life domains. The efficacy of the present management methods has not been established yet. We performed a prospective randomized controlled trial to explore the short-term efficacy of local analgesic (lidocaine) and opioid analgesic (sufentanil) in patients with CAPS.

Methods: We consecutively enrolled 130 patients who met the Rome IV CAPS criteria and divided them into the sufentanil + lidocaine (S + L) group and sufentanil (S) group. Patients completed the pain rating scales, including the numeric rating scale (NRS) and verbal rating scale (VRS), 60 min before colonoscopy. All the patients were initially administered sufentanil. In the S + L group, we sprayed a 5 ml solution of lidocaine on the surface of ascending, transverse, descending, and sigmoid colon during colonoscope withdrawal, while 5 ml saline was sprayed in the S group. Follow up was performed 1 day, 3 days, 1 week, 2 weeks, 1 month, and 3 months after colonoscopy, to complete the pain scaling.

Results: A comparison of the NRS and VRS showed that there were no significant differences between the S + L and S groups and within each group (p > 0.05).

Conclusions: Local analgesic lidocaine and opioid analgesic sufentanil showed negative efficacy during short-term observation. The opioid receptor blocker sufentanil did not worsen symptoms in patients with CAPS after colonoscopy under general anesthesia in the short term.[chictr.org.cn, Chinese Clinical Trial Identifier, ChiCTR-IOR-16008187].

Keywords: centrally mediated abdominal pain syndrome; lidocaine; sufentanil; treatment.

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Conflict of interest statement

Conflict of interest statement: The authors declare that there is no conflict of interest.

Figures

Figure 1.
Figure 1.
Flowchart of the whole study. CAPS, centrally mediated abdominal pain syndrome; NRS, numeric rating scale; VRS, verbal rating scale; S, sufentanil; S + L, sufentanil + lidocaine; SPSS, statistical software package for social sciences.
Figure 2.
Figure 2.
The CONSORT flowchart.
See this image and copyright information in PMC

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