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Case Reports
. 2021 Mar 23:5:PO.20.00468.
doi: 10.1200/PO.20.00468. eCollection 2021.

Lung Cancer in Li-Fraumeni Syndrome

Kathleen Kerrigan  1 , Jessica Chan  2 , Jennie Vagher  3 , Wendy Kohlmann  3 , Anne Naumer  3 , Jo Anson  3 , Sara Low  3 , Joshua Schiffman  4 , Luke Maese  4
Affiliations
Case Reports

Lung Cancer in Li-Fraumeni Syndrome

Kathleen Kerrigan et al. JCO Precis Oncol. .
No abstract available

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Figures

FIG 1.
FIG 1.
Adenocarcinoma in a patient with Li-Fraumeni syndrome with classic imaging appearance. A 15 × 6 × 6 mm nodule in the left lung apex with (A) solid and (B) subsolid components.
FIG 2.
FIG 2.
Adenocarcinoma in a patient with Li-Fraumeni syndrome in the left upper lung on whole-body MRI: (A) axial T2-HASTE and (B) axial DWI_TRACE.
See this image and copyright information in PMC

References

    1. Malkin D, Li FP, Strong LC, et al. : Germ line p53 mutations in a familial syndrome of breast cancer, sarcomas, and other neoplasms. Science 250:1233-1238, 1990 - PubMed
    1. Li FP, Fraumeni JF Jr: Soft-tissue sarcomas, breast cancer, and other neoplasms. A familial syndrome? Ann Intern Med 71:747-752, 1969 - PubMed
    1. McBride KA, Ballinger ML, Killick E, et al. : Li-Fraumeni syndrome: Cancer risk assessment and clinical management. Nat Rev Clin Oncol 11:260-271, 2014 - PubMed
    1. Caron O, Frebourg T, Benusiglio PR, et al. : Lung adenocarcinoma as part of the Li-Fraumeni syndrome spectrum: Preliminary data of the LIFSCREEN randomized clinical trial. JAMA Oncol 3:1736-1737, 2017 - PMC - PubMed
    1. Ballinger ML, Best A, Mai PL, et al. : Baseline surveillance in Li-Fraumeni syndrome using whole-body magnetic resonance imaging: A meta-analysis [published correction appears in JAMA Oncol 2018 Apr 1;4(4):590]. JAMA Oncol 3:1634-1639, 2017 - PMC - PubMed

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