Letter to the Editor in Response to Zhou et al

Sean Troth¹, Joan Butterton¹, Carisa Stadlman DeAnda¹, Patricia Escobar¹, Jay Grobler¹, Daria Hazuda¹, George Painter^{2

3

4}

Affiliations

¹ Merck & Co, Kenilworth, New Jersey, USA.
² Emory Institute of Drug Development, Emory University, Atlanta, Georgia, USA.
³ Drug Innovation Ventures at Emory, Atlanta, Georgia, USA.
⁴ Department of Pharmacology and Chemical Biology, Emory University, Atlanta, Georgia, USA.

Comment

Sean Troth et al. J Infect Dis. 2021.

. 2021 Oct 28;224(8):1442-1443.

doi: 10.1093/infdis/jiab362.

Sean Troth¹, Joan Butterton¹, Carisa Stadlman DeAnda¹, Patricia Escobar¹, Jay Grobler¹, Daria Hazuda¹, George Painter^{2

3

4}

¹ Merck & Co, Kenilworth, New Jersey, USA.
² Emory Institute of Drug Development, Emory University, Atlanta, Georgia, USA.
³ Drug Innovation Ventures at Emory, Atlanta, Georgia, USA.
⁴ Department of Pharmacology and Chemical Biology, Emory University, Atlanta, Georgia, USA.

No abstract available

Comment in

Reply to Troth et al.
Zhou S, Hill CS, Woodburn BMD, Schinazi RF, Swanstrom R. Zhou S, et al. J Infect Dis. 2021 Oct 28;224(8):1443-1444. doi: 10.1093/infdis/jiab363. J Infect Dis. 2021. PMID: 34255064 Free PMC article. No abstract available.

β-d-N4-hydroxycytidine Inhibits SARS-CoV-2 Through Lethal Mutagenesis But Is Also Mutagenic To Mammalian Cells.
Zhou S, Hill CS, Sarkar S, Tse LV, Woodburn BMD, Schinazi RF, Sheahan TP, Baric RS, Heise MT, Swanstrom R. Zhou S, et al. J Infect Dis. 2021 Aug 2;224(3):415-419. doi: 10.1093/infdis/jiab247. J Infect Dis. 2021. PMID: 33961695 Free PMC article.
Reply to Troth et al.
Zhou S, Hill CS, Woodburn BMD, Schinazi RF, Swanstrom R. Zhou S, et al. J Infect Dis. 2021 Oct 28;224(8):1443-1444. doi: 10.1093/infdis/jiab363. J Infect Dis. 2021. PMID: 34255064 Free PMC article. No abstract available.

1. Zhou S, Hill CS, Sarkar S, et al. . β-D-N 4-hydroxycytidine (NHC) inhibits SARS-CoV-2 through lethal mutagenesis but is also mutagenic to mammalian cells. J Infect Dis 2021;224:415–9. - PMC - PubMed
1. In vivo mammalian peripheral blood erythrocyte Pig-a mutation assay in rat (Charles River study no. 9800706). In: Data on file for MK-4482. Kenilworth, NJ: Merck & Co, 2021.
1. In vivo mutation assay at the cII locus in Big Blue® transgenic F344 rats (BioReliance study no. AG23CV.171E.BTL). In: Data on file for MK-4482. Kenilworth, NJ: Merck & Co, 2021.
1. OECD. Test no. 476: in vitro mammalian cell gene mutation tests using the Hprt and xprt genes. 2016. 10.1787/9789264264809-en. Accessed 7 June 2021. - DOI
1. Li AP, Gupta RS, Heflich RH, Wassom JS. A review and analysis of the Chinese hamster ovary/hypoxanthine guanine phosphoribosyl transferase assay to determine the mutagenicity of chemical agents: a report of phase III of the U.S. environmental protection agency gene-tox program. Mutat Res 1988; 196:17–36. - PubMed