Myelodysplastic Syndrome in a Patient with IPEX Syndrome

Daisuke Toyama^#^{1

2}, Akihiro Hoshino^#³, Kento Inoue³, Takahiro Kamiya³, Hirokazu Kanegane⁴, Shohei Yamamoto^{5

6}

Affiliations

¹ Department of Pediatrics, Showa University Fujigaoka Hospital, Yokohama, Kanagawa, Japan.
² Department of Pediatrics, Tokai University School of Medicine, Isehara, Kanagawa, Japan.
³ Department of Pediatrics and Developmental Biology Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University (TMDU), Tokyo, Japan.
⁴ Department of Child Health and Development, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University (TMDU), Tokyo, Japan.
⁵ Department of Pediatrics, Showa University Fujigaoka Hospital, Yokohama, Kanagawa, Japan. shohei-y@tsc.u-tokai.ac.jp.
⁶ Department of Pediatrics, Tokai University School of Medicine, Isehara, Kanagawa, Japan. shohei-y@tsc.u-tokai.ac.jp.

^# Contributed equally.

Case Reports

Daisuke Toyama et al. J Clin Immunol. 2021 Oct.

. 2021 Oct;41(7):1683-1685.

doi: 10.1007/s10875-021-01092-6. Epub 2021 Jul 12.

Daisuke Toyama^#^{1

2}, Akihiro Hoshino^#³, Kento Inoue³, Takahiro Kamiya³, Hirokazu Kanegane⁴, Shohei Yamamoto^{5

6}

¹ Department of Pediatrics, Showa University Fujigaoka Hospital, Yokohama, Kanagawa, Japan.
² Department of Pediatrics, Tokai University School of Medicine, Isehara, Kanagawa, Japan.
³ Department of Pediatrics and Developmental Biology Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University (TMDU), Tokyo, Japan.
⁴ Department of Child Health and Development, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University (TMDU), Tokyo, Japan.
⁵ Department of Pediatrics, Showa University Fujigaoka Hospital, Yokohama, Kanagawa, Japan. shohei-y@tsc.u-tokai.ac.jp.
⁶ Department of Pediatrics, Tokai University School of Medicine, Isehara, Kanagawa, Japan. shohei-y@tsc.u-tokai.ac.jp.

^# Contributed equally.

No abstract available

References

1. Gambineri E, Perroni L, Passerini L, et al. Clinical and molecular profile of a new series of patients with immune dysregulation, polyendocrinopathy, enteropathy, X-linked syndrome: inconsistent correlation between forkhead box protein 3 expression and disease severity. J Allergy Clin Immunol. 2008;122:1105-12.e1. - DOI
1. Hoshino A, Kanegane H, Nishi M, et al. Identification of autoantibodies using human proteome microarrays in patients with IPEX syndrome. Clin Immunol. 2019;203:9–13. - DOI
1. McMurchy AN, Gillies J, Allan SE, et al. Point mutants of forkhead box P3 that cause immune dysregulation, polyendocrinopathy, enteropathy, X-linked have diverse abilities to reprogram T cells into regulatory T cells. J Allergy Clin Immunol. 2010;126:1242–51. - DOI
1. Yamauchi T, Takasawa K, Kamiya T, et al. Hematopoietic stem cell transplantation recovers insulin deficiency in type 1 diabetes mellitus associated with IPEX syndrome. Pediatr Diabetes. 2019;20:1035–40. - DOI
1. Seidel MG. Autoimmune and other cytopenias in primary immunodeficiencies: pathomechanisms, novel differential diagnoses, and treatment. Blood. 2014;124:2337–44. - DOI