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. 2021 Sep;112(9):3924-3927.
doi: 10.1111/cas.15037. Epub 2021 Jul 12.

Low plasma fibrinogen levels are associated with poor prognosis in cutaneous angiosarcoma of the head and neck

Shoichiro Mori  1 , Tomoki Taki  1 , Yoshie Murakami  1 , Toru Urata  1 , Mao Okumura  1 , Honami Akanabe  1 , Aoi Ebata  1 , Satoko Imai  1 , Kenji Yokota  1 , Masashi Akiyama  1
Affiliations

Low plasma fibrinogen levels are associated with poor prognosis in cutaneous angiosarcoma of the head and neck

Shoichiro Mori et al. Cancer Sci. 2021 Sep.

Abstract

Angiosarcoma of the head and neck (ASHN) is one of the most aggressive malignancies of the skin, but the prognostic factors are not well known because of its rarity. Recently, high plasma fibrinogen levels were reported to predict poor prognosis in several malignancies. In the present retrospective study, we suggest that low plasma fibrinogen levels predict poor prognosis for ASHN.

Keywords: TNM staging; biomarker; guideline; prognostic factor; soft tissue sarcoma.

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Conflict of interest statement

Masashi Akiyama was provided a scholarship from Maruho Co. Ltd. The other authors have no conflict of interest.

Figures

FIGURE 1
FIGURE 1
Kaplan‐Meier method to determine overall survival (OS) rates in 22 patients with angiosarcoma of the head and neck. The OS rate is significantly higher in the high plasma fibrinogen group than in the low plasma fibrinogen group (P = .0027)
See this image and copyright information in PMC

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