Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2021 Jul 12;25(1):244.
doi: 10.1186/s13054-021-03662-x.

Emerging SARS-CoV-2 variants of concern and potential intervention approaches

Jasmin Khateeb  1   2 , Yuchong Li  1   3 , Haibo Zhang  4   5   6
Affiliations
Review

Emerging SARS-CoV-2 variants of concern and potential intervention approaches

Jasmin Khateeb et al. Crit Care. .

Abstract

The major variant of concerns (VOCs) have shared mutations in severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spike proteins, mostly on the S1 unit and resulted in higher transmissibility rate and affect viral virulence and clinical outcome. The spike protein mutations and other non-structural protein mutations in the VOCs may lead to escape approved vaccinations in certain extend. We will discuss these VOC mutations and discuss the need for combination therapeutic strategies targeting viral cycle and immune host responses.

Keywords: B.1.1.7; B.1.351; P.1. B.1617.1; Transmissibility; Viral virulence.

PubMed Disclaimer

Conflict of interest statement

The authors declare that they have no competing interests.

References

    1. COVID-19 daily epidemiology update - Canada.ca [Internet]. [cited 2021 May 8]. https://health-infobase.canada.ca/covid-19/epidemiological-summary-covid...
    1. Berry I, Soucy JPR, Tuite A, Fisman D. Open access epidemiologic data and an interactive dashboard to monitor the COVID-19 outbreak in Canada. CMAJ. Canadian Medical Association; 2020. p. E420. - PMC - PubMed
    1. Duchene S, Featherstone L, Haritopoulou-Sinanidou M, Rambaut A, Lemey P, Baele G. Temporal signal and the phylodynamic threshold of SARS-CoV-2. Virus Evol. 2020;6. - PMC - PubMed
    1. van Dorp L, Acman M, Richard D, Shaw LP, Ford CE, Ormond L, et al. Emergence of genomic diversity and recurrent mutations in SARS-CoV-2. Infect Genet Evol. 2020; 83. https://pubmed.ncbi.nlm.nih.gov/32387564/ - PMC - PubMed
    1. van Dorp L, Richard D, Tan CCS, Shaw LP, Acman M, Balloux F. No evidence for increased transmissibility from recurrent mutations in SARS-CoV-2. Nat Commun. 2020. https://pubmed.ncbi.nlm.nih.gov/33239633/ - PMC - PubMed

MeSH terms

Substances