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. 1987;70(1):25-30.

Short-term stimulation of lymphocyte proliferation by indomethacin in vitro and in vivo

R González-Cabello  1 , A Perl, L Kalmár, P Gergely
Affiliations
  • PMID: 3425329

Short-term stimulation of lymphocyte proliferation by indomethacin in vitro and in vivo

R González-Cabello et al. Acta Physiol Hung. 1987.

Abstract

The effect of short-term (up to 24 h) in vitro and in vivo treatment with indomethacin was studied on the blastogenesis of mouse spleen cells. Indomethacin in itself induced a strong proliferation of the lymphocytes starting after 6 h treatment both in vitro and in vivo. Besides, significantly enhanced the blastogenesis of splenocytes in response to various doses of PHA and Con A. The stimulation of lectin-induced lymphocyte proliferation occurred after indomethacin treatment both in vitro and in vivo. Indomethacin had no major effect on the distribution of Lyt-1+ and Lyt-2+ subsets within the spleen cell population. An important role of the prostaglandins in the early phase of lymphocyte activation is suggested.

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