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Review
. 2021 Oct;148(12):1406-1416.
doi: 10.1017/S0031182021001013. Epub 2021 Jun 18.

Congenital toxoplasmosis in humans: an update of worldwide rate of congenital infections

J P Dubey  1 , F H A Murata  1 , C K Cerqueira-Cézar  1 , O C H Kwok  1 , I Villena  2
Affiliations
Review

Congenital toxoplasmosis in humans: an update of worldwide rate of congenital infections

J P Dubey et al. Parasitology. 2021 Oct.

Erratum in

Abstract

The morbidity due to congenital toxoplasmosis in humans is very high. Most of these infected children are likely to develop symptoms of clinical toxoplasmosis. Sequelae in fetus resulting from Toxoplasma gondii infections in women who become infected with this parasite during pregnancy can be devastating and enormous efforts are directed in some countries to prevent these consequences. Here, an update on congenital toxoplasmosis in humans, especially the rate of congenital infections in humans worldwide, is provided. Although several countries have surveillance programmes, most information on the rate of congenital transmission is from France and Brazil. Because of compulsory national screening programme in France to detect and treat women with recently acquired T. gondii infection with anti-toxoplasma therapy, the rate of congenital transmission and the severity of disease in children are declining. Infections by this parasite are widely prevalent in Brazil. The severity of clinical toxoplasmosis in Brazilian children is very high and may be associated with the genetic characteristics of T. gondii isolates prevailing in animals and humans in Brazil. Virtually little or no information is available on this topic from China, India and other countries in Asia.

Keywords: Congenital toxoplasmosis; Toxoplasma gondii; humans; prevention; toxoplasmosis; worldwide.

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Conflict of interest statement

None.

Figures

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Graphical abstract
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References

    1. Abbas IE, Villena I and Dubey JP (2020) A review on toxoplasmosis in humans and animals from Egypt. Parasitology 147, 135–159. - PMC - PubMed
    1. Ajzenberg D, Cogné N, Paris L, Bessières MH, Thulliez P, Filisetti D, Pelloux H, Marty P and Dardé ML (2002) Genotype of 86 Toxoplasma gondii isolates associated with human congenital toxoplasmosis, and correlation with clinical findings. Journal of Infectious Diseases 186, 684–689. - PubMed
    1. Aptouramani M, Theodoridou M, Syrogiannopoulos G, Mentis A, Papaevangelou V, Gaitana K, Daponte A, Hadjichristodoulou C and The Toxoplasmosis Study Group of the Greece-Cyprus Pediatric Surveillance Unit (2012) A dedicated surveillance network for congenital toxoplasmosis in Greece, 2006–2009: assessment of the results. BMC Public Health 12, 1019. - PMC - PubMed
    1. Avelino MM, Amaral WN, Rodrigues IMX, Rassi AR, Gomes MBF, Costa TL and Castro AM (2014) Congenital toxoplasmosis and prenatal care state programs. BMC Infectious Diseases 14, 33. - PMC - PubMed
    1. Bénard A, Petersen E, Salamon R, Chêne G, Gilbert R and Salmi LR and for the European Toxo Prevention Study Group (EUROTOXO) (2008) Survey of European programmes for the epidemiological surveillance of congenital toxoplasmosis. Eurosurveillance 13, 18834. - PMC - PubMed

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