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. 2021 Jul 13;7(1):93.
doi: 10.1186/s40729-021-00373-4.

Clinical long-term and patient-reported outcomes of dental implants in oral cancer patients

Eik Schiegnitz  1 , Lena Katharina Müller  2 , Keyvan Sagheb  1 , Lisa Theis  1 , Vahide Cagiran  1 , Peer W Kämmerer  1 , Joachim Wegener  3 , Wilfried Wagner  1 , Bilal Al-Nawas  1
Affiliations

Clinical long-term and patient-reported outcomes of dental implants in oral cancer patients

Eik Schiegnitz et al. Int J Implant Dent. .

Abstract

Background and purpose: The aim of this clinical study was to investigate the clinical long-term and patient-reported outcome of dental implants in patients with oral cancer. In addition, analysis of the influence of radiation therapy, timing of implant insertion, and augmentation procedures on implant survival was performed.

Material and methods: This retrospective study investigated the clinical outcome of 711 dental implants in 164 oral cancer patients, inserted by experienced surgeons of the Department of Oral and Maxillofacial Surgery, University Medical Center Mainz, Germany. Oral health-related quality of life (OHRQoL) was evaluated.

Results: Cumulative 5-year and 10-year implant survival rates for all included implants were 87.3% and 80.0%. Implants placed straight after ablative surgery (primary implant placement) and implants placed after completing the oncologic treatment (secondary implant placement) showed a comparable implant survival (92.5% vs. 89.5%; p = 0.635). Irradiation therapy had no significant influence on implant survival of secondary placed implants (p = 0.929). However, regarding implant site (native bone vs. augmented bone) and radiation therapy (non-irradiated bone vs. irradiated bone), implants inserted in irradiated bone that received augmentation procedures showed a statistically significant lower implant survival (p < 0.001). Patients reported a distinct improvement in OHRQoL.

Conclusions: Promising long-term survival rates of dental implants in patients after treatment of oral cancer were seen. In addition, patients benefit in form of an improved OHRQoL. However, bone augmentation procedures in irradiated bone may result in an impaired implants' prognosis.

Keywords: Alveolar ridge reconstruction; Augmented bone; Dental implant; Irradiation; Long-term survival; Native bone; Oral cancer.

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Conflict of interest statement

There are no commercial or other associations that might create a duality of interests in connection with the article. Eik Schiegnitz reports lectures, personal fees, and/or grants from Dentsply, Geistlich, Medartis, Septodont, and Straumann outside the submitted work. Lena Müller declares that she has no conflict of interest. Keyvan Sagheb reports lectures, personal fees, and/or grants from Dentsply, Geistlich, and Straumann outside the submitted work. Lisa Theis declares that she has no conflict of interest. Vahide Cagiran declares that she has no conflict of interest. Peer Kämmerer reports lectures, personal fees, and/or grants from Sanofi-Aventis and Straumann outside the submitted work. Joachim Wegener declares that he has no conflict of interest. Wilfried Wagner reports lectures, personal fees, and/or grants from Camlog, Dentsply, Geistlich, Medartis, Straumann, and Zimmer outside the submitted work. Bilal Al-Nawas reports lectures, personal fees, and/or grants from Camlog, Dentsply, Geistlich, Medartis, Straumann, and Zimmer outside the submitted work.

Figures

Fig. 1
Fig. 1
Survival rates of primary and secondary placed implants (p = 0.635)
Fig. 2
Fig. 2
The influence of the implant site (native bone vs. augmented bone) and irradiation (non-irradiated bone vs. irradiated bone) on long-term survival (p < 0.001).
Fig. 3
Fig. 3
Responses to pre-worded statements after Mueller et al. [7] concerning changes in life effected by implant-supported prostheses (n = 165 implants)
See this image and copyright information in PMC

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