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. 2021 Aug;17(4):1083-1090.
doi: 10.1007/s12015-021-10203-0. Epub 2021 Jul 13.

The Brain: Is it a Next Frontier to Better Understand the Regulation and Control of Hematopoiesis for Future Modulation and Treatment?

Hal E Broxmeyer  1 , Karmen K Yoder  2 , Yu-Chien Wu  2 , Gary D Hutchins  2 , Scott H Cooper  3 , Sherif S Farag  4
Affiliations

The Brain: Is it a Next Frontier to Better Understand the Regulation and Control of Hematopoiesis for Future Modulation and Treatment?

Hal E Broxmeyer et al. Stem Cell Rev Rep. 2021 Aug.

Abstract

We wish to suggest the possibility there is a link between the brain and hematopoiesis in the bone marrow and that in the future it may be possible to use such information for better understanding of the regulation of hematopoiesis, and for efficacious treatment of hematopoietic disorders.

Keywords: Brain; Brain Imaging; Hematopoiesis; Hematopoietic Stem and Progenitor Cells; Microenvironment; NeuroTransmitter; Neurons.

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Conflict of interest statement

Conflicts of interest/Competing interests (include appropriate disclosures)

The authors have no conflicts of interest.

Figures

Figure 1.
Figure 1.
Diagrammatic representation of possible reasons for suggesting links between the brain and regulation of hematopoiesis and vice versa. A) Simplistic picture of brain-neuronal connections; B and C) Simplistic overview of neural regulation of hematopoiesis, inflammation and cancer (7); and D) Simplistic rendition of the BM microenvironment (19).
Figure 2.
Figure 2.
Potential means to currently evaluate brain-organ links. A.) Diagrammatic representation of assessing the brain and organ responses. PNS: peripheral nervous system. ANS: autonomic nervous system. CNS: central nervous system. CBV: cerebral blood volume. CBF: cerebral blood flow. CMRO2: cerebral metabolic rate of oxygen. The hemodynamic response function is a parameter used in functional magnetic resonance imaging to estimate relative changes in blood oxygenation levels. B. Representative brain networks observed in human subjects with functional fMRI. C. Top: Representative maps of quantitative blood flow (cerebral blood flow, CBF, mL/100 g/min). Bottom: Representative maps of arterial transit time (ATT; m sec) from the same data acquisition. Data were acquired in a single subject with an MRI method called pseudo-continuous arterial spin labeling (pCASL). Similar technology can be applied to rodents with high-field small animal MRI systems, with the result being translational information about rodent and human brain networks and brain blood flow. See article by Khalili-Mahani et al (45).
See this image and copyright information in PMC

References

    1. Holt J. (2018). When Einstein walked with Gödel : excursions to the edge of thought. Publisher: New York: : Farrar, Straus and Giroux. pp. 1–384.
    1. Goolsby J, Marty MC, Heletz D, Chiappelli J, Tashko G, Yarnell D, Fishman PS, Dhib-Jalbut S, Bever CT Jr, Pessac B, & Trisler D. (2003). Hematopoietic progenitors express neural genes. Proceedings of the National Academy of Sciences of the United States of America, 100(25), 14926–14931. 10.1073/pnas.2434383100 - DOI - PMC - PubMed
    1. Steidl U, Bork S, Schaub S, Selbach O, Seres J, Aivado M, Schroeder T, Rohr UP, Fenk R, Kliszewski S, Maercker C, Neubert P, Bornstein SR, Haas HL, Kobbe G, Tenen DG, Haas R, & Kronenwett R. (2004). Primary human CD34+ hematopoietic stem and progenitor cells express functionally active receptors of neuromediators. Blood, 104(1), 81–88. 10.1182/blood-2004-01-0373 - DOI - PubMed
    1. Spiegel A, Shivtiel S, Kalinkovich A, Ludin A, Netzer N, Goichberg P, Azaria Y, Resnick I, Hardan I, Ben-Hur H, Nagler A, Rubinstein M, & Lapidot T. (2007). Catecholaminergic neurotransmitters regulate migration and repopulation of immature human CD34+ cells through Wnt signaling. Nature immunology, 8(10), 1123–1131. 10.1038/ni1509 - DOI - PubMed
    1. Kalinkovich A, Spiegel A, Shivtiel S, Kollet O, Jordaney N, Piacibello W, & Lapidot T. (2009). Blood-forming stem cells are nervous: direct and indirect regulation of immature human CD34+ cells by the nervous system. Brain, behavior, and immunity, 23(8), 1059–1065. 10.1016/j.bbi.2009.03.008 - DOI - PubMed

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