Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2021 Jul 12;39(7):885-888.
doi: 10.1016/j.ccell.2021.06.012.

The role of exhaustion in CAR T cell therapy

Greg M Delgoffe, Chenqi Xu, Crystal L Mackall, Michael R Green, Stephen Gottschalk, Daniel E Speiser, Dietmar Zehn, Paul A Beavis
Free article

The role of exhaustion in CAR T cell therapy

Greg M Delgoffe et al. Cancer Cell. .
Free article

Abstract

CAR T cell therapy successes are challenged by several mechanisms of resistance including the development of dysfunctional states such as exhaustion. The features of CAR T cell exhaustion, its role in limiting the efficacy of CAR T therapy in both liquid and solid malignancies, and potential strategies to overcome it are discussed.

PubMed Disclaimer

MeSH terms

Substances

LinkOut - more resources