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Comment
. 2021 Jul 12;39(7):902-904.
doi: 10.1016/j.ccell.2021.06.008.

I-SPY2 platform: New lessons from the olaparib and durvalumab combination in breast cancer treatment

Jose Perez-Garcia  1 , Maria Gion  2 , Javier Cortes  3
Affiliations
Free article
Comment

I-SPY2 platform: New lessons from the olaparib and durvalumab combination in breast cancer treatment

Jose Perez-Garcia et al. Cancer Cell. .
Free article

Abstract

I-SPY2 platform-based phase II studies in breast cancer might speed up the development of new treatments. In this issue of Cancer Cell, Pusztai et al. report that adding durvalumab and olaparib to standard neoadjuvant chemotherapy significantly increases the pathological complete response rate in patients with HER2-negative breast cancer irrespective of the hormone receptor status.

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Conflict of interest statement

Declaration of interests Javier Cortes is a consultant for AstraZeneca, Daiichi Sankyo, and MSD, and he is paid honoraria by MSD and Daiichi Sankyo. Jose Perez-Garcia is a consultant for AstraZeneca. The authors declare no other conflicts of interest related to the work.

Comment on

  • Durvalumab with olaparib and paclitaxel for high-risk HER2-negative stage II/III breast cancer: Results from the adaptively randomized I-SPY2 trial.
    Pusztai L, Yau C, Wolf DM, Han HS, Du L, Wallace AM, String-Reasor E, Boughey JC, Chien AJ, Elias AD, Beckwith H, Nanda R, Albain KS, Clark AS, Kemmer K, Kalinsky K, Isaacs C, Thomas A, Shatsky R, Helsten TL, Forero-Torres A, Liu MC, Brown-Swigart L, Petricoin EF, Wulfkuhle JD, Asare SM, Wilson A, Singhrao R, Sit L, Hirst GL, Berry S, Sanil A, Asare AL, Matthews JB, Perlmutter J, Melisko M, Rugo HS, Schwab RB, Symmans WF, Yee D, Van't Veer LJ, Hylton NM, DeMichele AM, Berry DA, Esserman LJ. Pusztai L, et al. Cancer Cell. 2021 Jul 12;39(7):989-998.e5. doi: 10.1016/j.ccell.2021.05.009. Epub 2021 Jun 17. Cancer Cell. 2021. PMID: 34143979 Free PMC article. Clinical Trial.

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