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Comment
. 2021 Jul 12;39(7):907-909.
doi: 10.1016/j.ccell.2021.06.006.

Is glucose the scapegoat for tumor evasion?

Lydia N Raines  1 , Stanley Ching-Cheng Huang  2
Affiliations
Free article
Comment

Is glucose the scapegoat for tumor evasion?

Lydia N Raines et al. Cancer Cell. .
Free article

Abstract

Tumor cells undergo rapid aerobic glycolysis to fuel growth and proliferation. A recent finding in Nature reveals that tumor-infiltrating myeloid cells demonstrate greater capacity for glucose uptake than tumor cells and consume significant amounts within the tumor milieu. Unexpectedly, tumor cells account for the highest glutamine utilization in the tumor microenvironment.

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Conflict of interest statement

Declaration of interests The authors declare no competing interests.

Comment on

  • Cell-programmed nutrient partitioning in the tumour microenvironment.
    Reinfeld BI, Madden MZ, Wolf MM, Chytil A, Bader JE, Patterson AR, Sugiura A, Cohen AS, Ali A, Do BT, Muir A, Lewis CA, Hongo RA, Young KL, Brown RE, Todd VM, Huffstater T, Abraham A, O'Neil RT, Wilson MH, Xin F, Tantawy MN, Merryman WD, Johnson RW, Williams CS, Mason EF, Mason FM, Beckermann KE, Vander Heiden MG, Manning HC, Rathmell JC, Rathmell WK. Reinfeld BI, et al. Nature. 2021 May;593(7858):282-288. doi: 10.1038/s41586-021-03442-1. Epub 2021 Apr 7. Nature. 2021. PMID: 33828302 Free PMC article.

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