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Comment
. 2021 Jul 12;39(7):910-912.
doi: 10.1016/j.ccell.2021.06.011.

Learning from BISCAY: The future of biomarker-based trial design in bladder cancer

Luis Meza  1 , Nicholas J Salgia  2 , Kalen C Patel  1 , Sumanta K Pal  3
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Learning from BISCAY: The future of biomarker-based trial design in bladder cancer

Luis Meza et al. Cancer Cell. .
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Abstract

A recent article in Nature Medicine explored the combination of immunotherapy with multiple distinct targeted therapies in patients with metastatic urothelial cancer, employing a biomarker-driven approach. Herein, we discuss the merits of this ambitious study and highlight the need for larger biomarker-based randomized trials to arrive at definitive clinical conclusions.

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Conflict of interest statement

Declaration of interests S.K.P. declares the following: honoraria—Novartis, Medivation, and Astellas Pharma; consulting or advisory role—Pfizer, Novartis, Aveo, and Myriad; pharmaceuticals—Genentech, Exelixis, Bristol-Myers Squibb, and Astellas Pharma; and research funding—Medivation.

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