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. 2021 Apr 30:27:598862.
doi: 10.3389/pore.2021.598862. eCollection 2021.

Age and Gender Specific Lung Cancer Incidence and Mortality in Hungary: Trends from 2011 Through 2016

Lilla Tamási  1 , Krisztián Horváth  2 , Zoltán Kiss  3 , Krisztina Bogos  4 , Gyula Ostoros  4 , Veronika Müller  1 , László Urbán  5 , Nóra Bittner  6 , Veronika Sárosi  7 , Aladár Vastag  3 , Zoltán Polányi  3 , Zsófia Nagy-Erdei  3 , Andrea Daniel  3 , Balázs Nagy  2 , György Rokszin  8 , Zsolt Abonyi-Tóth  8   9 , Judit Moldvay  10   11 , Zoltán Vokó  2 , Gabriella Gálffy  1   12
Affiliations

Age and Gender Specific Lung Cancer Incidence and Mortality in Hungary: Trends from 2011 Through 2016

Lilla Tamási et al. Pathol Oncol Res. .

Abstract

Objective: No assessment was conducted describing the age and gender specific epidemiology of lung cancer (LC) prior to 2018 in Hungary, thus the objective of this study was to appraise the detailed epidemiology of lung cancer (ICD-10 C34) in Hungary based on a retrospective analysis of the National Health Insurance Fund database. Methods: This longitudinal study included patients aged ≥20 years with LC diagnosis (ICD-10 C34) between January 1, 2011 and December 31, 2016. Patients with different cancer-related codes 6 months before or 12 months after LC diagnosis or having any cancer treatment other than lung cancer protocols were excluded. Results: Lung cancer incidence and mortality increased with age, peaking in the 70-79 age group (375.0/100,000 person-years) among males, while at 60-69 age group for females (148.1/100,000 person-years). The male-to-female incidence rate ratio reached 2.46-3.01 (p < 0.0001) among the 70-79 age group. We found 2-11% decrease in male incidence rate at most age groups, while a significant 1-3% increase was observed in older females (>60) annually during the study period. Conclusion: This nationwide epidemiology study demonstrated that LC incidence and mortality in Hungary decreased in younger male and female population, however we found significant increase of incidence in older female population, similar to international trends. Incidence rates peaked in younger age-groups compared to Western countries, most likely due to higher smoking prevalence in these cohorts, while lower age LC incidence could be attributed to higher competing cardiovascular risk resulting in earlier mortality in smoking population.

Keywords: age and gender; epidemiology; incidence; lung cancer; mortality.

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Conflict of interest statement

ZK, AV, and ZN-E, and AD are employees of MSD Pharma Hungary Ltd. KH is a research fellow at Eötvös Loránd University. BN and ZV are employees of Eötvös Loránd University where their contribution to this project was financially compensated. KB and GO are employees of National Korányi Institute of Pulmonology and have received speaker honorarium from MSD Hungary. GG is employee of Oncology Center of Törökbálint and has received speaker honorarium from MSD Hungary, LT and VM are employees of Semmelweis University and they declare have no conflict of interest, LU is employee of MG and he declares have no conflict of interest, NB is employee of University of Debrecen and she declares have no conflict of interest, VS is employee of University of Pécs and she declares have no conflict of interest. GR and ZA-T are employees of RxTarget Ltd. where their contribution to this project was financially compensated. ZB is employees of Synthesia Ltd. And her contribution to this project was financially compensated. The authors declare that this study received funding from MSD Pharma Hungary Ltd. The funder had the following involvement with the study: study design, data collection and analysis. The remaining authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Figures

FIGURE 1
FIGURE 1
(A) Age-specific incidence rates and number of new lung cancer patients by sex in 2011 (B) Male-to-female incidence rate ratios by age cohorts in 2011 (C) Age-specific incidence rates and number of new lung cancer patients by sex in 2016 (D) Male-to-female incidence rate ratios by age cohorts in 2016. CI, confidence interval; LC, lung cancer.
FIGURE 2
FIGURE 2
(A) Incidence rate ratios by age groups in men in 2016 vs. 2011. (B) Incidence rate ratios by age groups in women in 2016 vs. 2011. CI, confidence interval; LC, lung cancer.
FIGURE 3
FIGURE 3
(A) Age-specific mortality rates and number of lung cancer death by sex in 2011 (B) Male-to-female mortality rate ratios by age cohorts in 2011 (C) Age-specific mortality rates and number of lung cancer death by sex in 2016 (D) Male-to-female mortality rate ratios by age cohorts in 2016. CI, confidence interval; LC, lung cancer.
FIGURE 4
FIGURE 4
(A) Mortality rate ratios by age groups in 2016 vs. 2011 in men (B) Mortality rate ratios by age groups in 2016 vs. 2011 in women. CI, confidence interval; LC, lung cancer.
See this image and copyright information in PMC

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