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Review
. 2021 Jun 24:2021:9927433.
doi: 10.1155/2021/9927433. eCollection 2021.

Antibody-Drug Conjugates Used in Breast Cancers

Aram J Abbas  1 , Marah F Ibrahim  2 , Maher S Saifo  1   2
Affiliations
Review

Antibody-Drug Conjugates Used in Breast Cancers

Aram J Abbas et al. J Oncol. .

Abstract

The prognosis of breast cancer has radically changed in recent years and continues to improve due to the broad application of effective therapies. New targeting strategies including targeted delivery of cytotoxic drugs via receptor-targeting agents have been developed. We summarize recent publications and developments of novel antibody-drug conjugates (ADCs) used to control breast cancer.

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Conflict of interest statement

The authors declare that there are no conflicts of interest regarding the publication of this paper.

Figures

Figure 1
Figure 1
Structure of an antibody-drug conjugate [19].
See this image and copyright information in PMC

References

    1. World Health Organization. Cancer. Berlin, Germany: World Health Organization; 2018. https://www.who.int/news-room/fact-sheets/detail/cancer.
    1. Sung H. Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA: A Cancer Journal for Clinicians. 2021;71(1) doi: 10.3322/caac.21660. - DOI - PubMed
    1. Slamon D., Clark G., Wong S., Levin W., Ullrich A., McGuire W. Human breast cancer: correlation of relapse and survival with amplification of the HER-2/neu oncogene. Science. 1987;235(4785):177–182. doi: 10.1126/science.3798106. - DOI - PubMed
    1. Siegel R. L., Miller K. D., Jemal A. Cancer statistics, 2020. CA: A Cancer Journal for Clinicians. 2020;70(1):7–30. doi: 10.3322/caac.21590. - DOI - PubMed
    1. Sun Y.-S., Zhao Z., Yang Z.-N., et al. Risk factors and preventions of breast cancer. International Journal of Biological Sciences. 2017;13(11):1387–1397. doi: 10.7150/ijbs.21635. - DOI - PMC - PubMed

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