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Review
. 2021 Jun 25:2021:5471347.
doi: 10.1155/2021/5471347. eCollection 2021.

Role of Polyphenols as Antioxidant Supplementation in Ischemic Stroke

Yuan Zhou  1 , Shanshan Zhang  1 , Xiang Fan  1   2
Affiliations
Review

Role of Polyphenols as Antioxidant Supplementation in Ischemic Stroke

Yuan Zhou et al. Oxid Med Cell Longev. .

Abstract

Stroke is the second most common cause of death globally and the leading cause of death in China. The pathogenesis of cerebral ischemia injury is complex, and oxidative stress plays an important role in the fundamental pathologic progression of cerebral damage in ischemic stroke. Previous studies have preliminarily confirmed that oxidative stress should be a potential therapeutic target and antioxidant as a treatment strategy for ischemic stroke. Emerging experimental studies have demonstrated that polyphenols exert the antioxidant potential to play the neuroprotection role after ischemic stroke. This comprehensive review summarizes antioxidant effects of some polyphenols, which have the most inhibition effects on reactive oxygen species generation and oxidative stress after ischemic stroke.

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Conflict of interest statement

The authors declared that there was no potential conflict of interest.

Figures

Figure 1
Figure 1
The chemical structures and plant origin of some common polyphenols and their classifications.
Figure 2
Figure 2
Molecular mechanisms of polyphenols as antioxidant supplementations in ischemic stroke.
See this image and copyright information in PMC

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