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. 2021 Jun 24:2021:9969825.
doi: 10.1155/2021/9969825. eCollection 2021.

Conjugated Hyperbilirubinemia in Infants: Is There Still a Role for ERCP?

Jan Stovicek  1 , Stepan Hlava  1 , Radan Keil  1 , Jiri Drabek  1 , Jindra Lochmannova  1 , Petra Koptová  1 , Martin Wasserbauer  1 , Barbora Frybova  2 , Jiri Snajdauf  2 , Radana Kotalova  3 , Michal Rygl  2
Affiliations

Conjugated Hyperbilirubinemia in Infants: Is There Still a Role for ERCP?

Jan Stovicek et al. Can J Gastroenterol Hepatol. .

Abstract

Over a twenty-year period, we performed 255 ERCP procedures in infants aged up to 1 year. ERCP was indicated in cholestatic infants with suspicion of biliary obstruction. The most common diagnosis was biliary atresia (48%), choledochal cysts (13%), and choledocholithiasis (4%). The procedure complication rate was 13.7%. Hyperamylasemia occurred in 12.9%. More severe complications were rare-0.8% of ERCP procedure. There were no cases of postprocedural pancreatitis or death. Our study has proved that ERCP is a safe and reliable method in this age group. Its high specificity and negative predictive value for extrahepatic biliary atresia can prevent unnecessary surgeries in patients with normal bile ducts or endoscopically treatable pathologies.

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Conflict of interest statement

The authors declare that they have no conflicts of interest.

Figures

Figure 1
Figure 1
Diagnostic algorithm for conjugated hyperbilirubinemia.
Figure 2
Figure 2
Todani classification of biliary cysts.
Figure 3
Figure 3
Age distribution of infants with biliary atresia at the time of diagnosis.
Figure 4
Figure 4
Number of biliary atresia by the month of birth and diagnosis.
See this image and copyright information in PMC

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