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Review
. 2021 Jun 23:2021:6707464.
doi: 10.1155/2021/6707464. eCollection 2021.

Potential Functions of the BMP Family in Bone, Obesity, and Glucose Metabolism

Yao Chen  1 , Bingwei Ma  2 , Xingchun Wang  3 , Xiaojuan Zha  3 , Chunjun Sheng  3 , Peng Yang  3 , Shen Qu  3
Affiliations
Review

Potential Functions of the BMP Family in Bone, Obesity, and Glucose Metabolism

Yao Chen et al. J Diabetes Res. .

Abstract

Characteristic bone metabolism was observed in obesity and diabetes with controversial conclusions. Type 2 diabetes (T2DM) and obesity may manifest increased bone mineral density. Also, obesity is more easily to occur in T2DM. Therefore, we infer that some factors may be linked to bone and obesity as well as glucose metabolism, which regulate all of them. Bone morphogenetic proteins (BMPs), belonging to the transforming growth factor- (TGF-) beta superfamily, regulate a diverse array of cellular functions during development and in the adult. More and more studies revealed that there exists a relationship between bone metabolism and obesity as well as glucose metabolism. BMP2, BMP4, BMP6, BMP7, and BMP9 have been shown to affect the pathophysiological process of obesity and glucose metabolism beyond bone metabolism. They may exert functions in adipogenesis and differentiation as well as insulin resistance. In the review, we summarize the literature on these BMPs and their association with metabolic diseases including obesity and diabetes.

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Conflict of interest statement

The authors declare that they have no competing interests.

Figures

Figure 1
Figure 1
Effects of BMPs (BMP9, BMP4, BMP2, BMP7, and BMP6) on bone, obesity, and glucose metabolism. BMP: bone morphogenetic protein; WAT: white adipose tissue; BAT: brown adipose tissue; IR: insulin resistance; SAT: subcutaneous adipose tissue; VAT: visceral adipose tissue; BMD: bone mineral density.
Figure 2
Figure 2
BMP9 enhanced expression of FGF21 reduces a serum level of ALT as well as cholesterol and enhances brown adipogenesis, resulting in suppression of NAFLD and obesity.
Figure 3
Figure 3
BMP7 can regulate brown adipogenesis and energy expenditure.
See this image and copyright information in PMC

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