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Case Reports
. 2021 Jun 23:37:100818.
doi: 10.1016/j.gore.2021.100818. eCollection 2021 Aug.

Isolated splenic high-grade serous carcinoma: A case report

Ralph Rogers  1   2 , Sarah Ehmann  1 , William P Tew  3   4 , Vance Broach  1   5
Affiliations
Case Reports

Isolated splenic high-grade serous carcinoma: A case report

Ralph Rogers et al. Gynecol Oncol Rep. .

Abstract

We present a unique case of high-grade serous carcinoma isolated to the spleen at the time of diagnosis, without any tumor present in the ovary, fallopian tubes, omentum or uterus, which was pathologically consistent with metastatic Mullerian carcinoma. Tumor sequencing with the MSK-IMPACT (Memorial Sloan Kettering-Integrated Mutation Profiling of Actionable Cancer Targets) multigene tumor panel test was performed, which revealed somatic mutations in PALB2 and in ARID1, as well as a TP53 hotspot mutation.

Keywords: ARID1 somatic mutation; High-grade serous carcinoma; PALB2 mutation; Pluripotent spleen cell; Splenic Mullerian carcinoma; TP53 hotspot mutation.

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Conflict of interest statement

The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.

Figures

Fig. 1
Fig. 1
CT scan showing normal reproductive organs.
Fig. 2
Fig. 2
CT scan showing splenic mass.
Fig. 3
Fig. 3
PET-CT scan showing splenic mass.
See this image and copyright information in PMC

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