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Review
. 2021 Oct;107(4):383-392.
doi: 10.1111/ejh.13688. Epub 2021 Jul 29.

The hemostatic and thrombotic complications of liver disease

Hannah Stowe McMurry  1 , Janice Jou  2 , Joseph Shatzel  3   4
Affiliations
Review

The hemostatic and thrombotic complications of liver disease

Hannah Stowe McMurry et al. Eur J Haematol. 2021 Oct.

Abstract

Hepatic cirrhosis leads to numerous hematologic derangements resulting in a complex and tenuously rebalanced hemostatic milieu. The utility of common hematologic tests including the INR and aPTT in assessing hemostatic and thrombotic risk in patients with cirrhosis is limited, and consensus on transfusion thresholds and proper management of thrombotic complications continues to evolve. This review summarizes the pathophysiology of key derangements of hemostasis including those of platelets, von Willebrand factor, pro- and anticoagulation factors, and fibrin. Additionally, the pathogenesis, consequences, optimal management, and prevention of major thrombotic and bleeding complications in cirrhosis arte discussed.

Keywords: blood coagulation; hemostasis; humans; liver cirrhosis; thrombosis.

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Conflict of interest statement

CONFLICT OF INTEREST

None.

Figures

FIGURE 1
FIGURE 1
Pathogenesis of hematologic derangements of cirrhosis Created with biorender.com
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