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. 2021 Oct 1;40(10):912-916.
doi: 10.1097/INF.0000000000003271.

Response to Vaccination in Infants Exposed to Antitumor Necrosis Factor Alpha In Utero

Jantien W Wieringa  1 , Ron H T van Beek  2 , Lyanne W Rövekamp  3 , Gertjan J A Driessen  3   4 , Herbert M van Wering  2
Affiliations

Response to Vaccination in Infants Exposed to Antitumor Necrosis Factor Alpha In Utero

Jantien W Wieringa et al. Pediatr Infect Dis J. .

Abstract

In this retrospective cohort study, the response to routinely administered Haemophilus influenzae type B vaccine, pneumococcal and pertussis vaccinations in 27 children exposed to antitumor necrosis factor alpha (anti-TNFα) during pregnancy was measured. The overall vaccination response seems comparable for children exposed to anti-TNFα and healthy infants. After primary vaccination series, inadequate response was present in some patients and might be related to exposure to anti-TNFα.

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Conflict of interest statement

J.W.W. had received a research grant from the Dr CJ Vaillant Foundation. G.D. had received a research grant from Elisabeth von Freyburg, research grant Sophia Research Foundation and a research grant Dr CJ Vaillant Foundation. R.H.T.B. is a member of the Nutricia advisory board. The other authors have no conflicts of interest to disclose.

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